2'-O-METHYLADENOSINE

CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=NC3=C2N=CN=C3N

InChIKey=FPUGCISOLXNPPC-IOSLPCCCSA-N

InChI=1S/C11H15N5O4/c1-19-8-7(18)5(2-17)20-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Targets

Primary Target	Pharmacology	Condition	Potency
RNA 19 Target ID: RNA Sources: https://www.ncbi.nlm.nih.gov/pubmed/9383369 \| https://www.ncbi.nlm.nih.gov/pubmed/22496660	Modulator 828

PubMed

Title	Date	PubMed
The role of magnesium ions and 2'-hydroxyl groups in the VS ribozyme-substrate interaction.	2002 Nov 22	12441101
Use of nucleotide analogs by class I and class II CCA-adding enzymes (tRNA nucleotidyltransferase): deciphering the basis for nucleotide selection.	2003 Aug	12869708
Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.	2004 Apr 22	15084127
Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.	2007 Aug 9	17636948
Modifications in small interfering RNA that separate immunostimulation from RNA interference.	2008 Mar 1	18292547
Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana.	2010 Sep 14	20836892

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:41:54 GMT 2023` Edited by `admin` on `Fri Dec 15 18:41:54 GMT 2023`
Record UNII	02YX82IHZ5
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

2'-O-METHYLADENOSINE

Systematic Name

English

ADENOSINE, 2'-O-METHYL-

Systematic Name

English

Code System Code Type Description

MESH

C024341