TECNAZENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6HCl4NO2
Molecular Weight	260.89
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+](=O)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl

InChI

InChIKey=XQTLDIFVVHJORV-UHFFFAOYSA-N

InChI=1S/C6HCl4NO2/c7-2-1-3(8)5(10)6(4(2)9)11(12)13/h1H

HIDE SMILES / InChI

Molecular Formula	C6HCl4NO2
Molecular Weight	260.89
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://sitem.herts.ac.uk/aeru/ppdb/en/Reports/615.htm | https://www.ncbi.nlm.nih.gov/pubmed/18800534 | http://www.fao.org/fileadmin/templates/agphome/documents/Pests_Pesticides/JMPR/Evaluation94/tecnaz.pdf

Tecnazene, also known as 2,3,5,6-tetrachloro-1-nitrobenzene or tcnb, is a member of the class of compounds known as nitrobenzenes. Tecnazene is a dual acting pesticide. It is used as a plant growth regulator to suppress sprouts on potatoes during storage and as a fungicide to prevent dry rot on the tubers. Human exposure is primarily through ingestion of food residues, with an Acceptable Daily Intake level of 0.01 mg/kg of body weight according to FAO/WHO guidelines. Tecnazene is commercially available as granules and as dispersible dust formulations.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Enhancement by non-mutagenic pesticides of GST-P positive hepatic foci development initiated with diethylnitrosamine in the rat.	1993 Aug 16	8402576
Ion chromatographic determination of the decomposition products of tecnazene solution irradiated by ultraviolet light: inorganic and organic anions.	2001 Jun	11409977
Residues of 18 organochlorine pesticides in 30 traditional Chinese medicines.	2008 Apr	18160094
Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS.	2008 Sep 1	18800534
Multiresidue pesticide analysis of botanical dietary supplements using salt-out acetonitrile extraction, solid-phase extraction cleanup column, and gas chromatography-triple quadrupole mass spectrometry.	2013 May 7	23534560

Patents

Sample Use Guides

In Vivo Use Guide

The metabolic fate of [U-14C]-2,3,5,6-tetrachloronitrobenzene (tecnazene) has been determined in the male and female rat following a single dose of 1 mg/kg and in surgically prepared, bile-duct-cannulated rats following a single oral dose of 135 mg/kg.

Route of Administration: Oral

In Vitro Use Guide

Two doses of tecnazene dissolved in acetone, corresponding to 103 and 864 ug/cm2 of tecnazene, were applied to skin mounted on Franz diffusion cells and placed in a fume hood. Cells were either occluded withaluminumfoilorleftunoccluded.Totalabsorptionoftecnazene (dermis + receptor fluid) after 48 h was 2.2-6.1% of the applied dose for the unoccluded treatments and 22-33% for the occluded treatments. Potentially absorbed dose including all tecnazene that may have eventually permeated the skin rangedfrom 10% unoccludedto 42-53% occluded.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:14:52 GMT 2023` Edited by `admin` on `Fri Dec 15 15:14:52 GMT 2023`
Record UNII	02X6KNJ5EE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TECNAZENE

Common Name

English

BENZENE, 1,2,4,5-TETRACHLORO-3-NITRO-

Systematic Name

English

TCNB

Common Name

English

CHIPMAN-3142

Code

English

TECNAZENE [ISO]

Common Name

English

NEBULIN

Brand Name

English

FOLOSAN

Brand Name

English

NAPOTATE

Brand Name

English

TECNAZEN

Common Name

English

MYFUSAN

Brand Name

English

TECNAZENE [HSDB]

Common Name

English

2,3,5,6-TETRACHLORONITROBENZENE

Systematic Name

English

NSC-10235

Code

English

1-NITRO-2,3,5,6-TETRACHLOROBENZENE

Systematic Name

English

2,3,5,6-TETRACHLORO-1-NITROBENZENE

Systematic Name

English

TETRACHLORONITROBENZENE

Systematic Name

English

1,2,4,5-TETRACHLORO-3-NITROBENZENE

Systematic Name

English

FUSAREX

Brand Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

55201