KYOTORPHIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H23N5O4
Molecular Weight	337.3742
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

InChIKey=JXNRXNCCROJZFB-RYUDHWBXSA-N

InChI=1S/C15H23N5O4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C15H23N5O4
Molecular Weight	337.3742
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
[Effect of kyotorphin on the seizure activity induced by kainic acid during picrotoxin kindling in rats].	1998 Jan-Feb	9612866
Synthesis and analgesic effects of kyotorphin-steroid linkers.	2001 Nov	11576620
[Morpho-functional changes of Mauthner neurons after treatment with neuropeptide kyotorphin ].	2002	12530306
Blockade of the antinociceptive effect of spinally administered kyotorphin by naltrindole in mice.	2002 Apr 5	11958852
[Therapy of postresuscitation behavioral disorders with mexidol and kyotorphin].	2002 Nov-Dec	12611163
Involvement of nitric oxide in the nociception of kyotorphin, TYR-CAV and MIF-s analogues in the rat spinal cord.	2003 Mar	12731454
Kyotorphin suppresses proliferation and Ca2+ signaling in brown preadipocytes.	2006 Feb	16984102
Chiral recognition of D-kyotorphin by lipidic membranes: relevance toward improved analgesic efficiency.	2006 Jul	16902926
Vascular effects, angiotensin I-converting enzyme (ACE)-inhibitory activity, and antihypertensive properties of peptides derived from egg white.	2007 Dec 26	18047278
The pH-dependent conformational states of kyotorphin: a constant-pH molecular dynamics study.	2007 Mar 15	17172294
Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2.	2008	18762712
Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC molecules.	2008 Mar 19	18350151
[Functional arginine-containing amino acid sequences in peptides and proteins].	2008 Mar-Apr	18522270
Moisture-induced solid state instabilities in alpha-chymotrypsin and their reduction through chemical glycosylation.	2010 Aug 9	20696067
Membrane-induced conformational changes of kyotorphin revealed by molecular dynamics simulations.	2010 Sep 9	20707376

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:05:06 GMT 2023` Edited by `admin` on `Fri Dec 15 18:05:06 GMT 2023`
Record UNII	02N30CW3X0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KYOTORPHIN

Common Name

English

DIPEPTIDE-1

Official Name

English

DIPEPTIDE-1 [INCI]

Common Name

English

L-TYROSYL-L-ARGININE

Systematic Name

English

TYR-ARG

Common Name

English

Code System Code Type Description

CHEBI

58184