Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C15H23N5O4 |
| Molecular Weight | 337.3742 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
InChI
InChIKey=JXNRXNCCROJZFB-RYUDHWBXSA-N
InChI=1S/C15H23N5O4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1
| Molecular Formula | C15H23N5O4 |
| Molecular Weight | 337.3742 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Membrane-induced conformational changes of kyotorphin revealed by molecular dynamics simulations. | 2010-09-09 |
|
| Moisture-induced solid state instabilities in alpha-chymotrypsin and their reduction through chemical glycosylation. | 2010-08-09 |
|
| Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes. | 2010-08-06 |
|
| Eryngase: a Pleurotus eryngii aminopeptidase exhibiting peptide bond formation activity. | 2010-08 |
|
| The Analgesic Activity of Bestatin as a Potent APN Inhibitor. | 2010 |
|
| [Temperature and cardiotropic effects of kyotorphin and neokyotorphin in hibernating and nonhibernating animals]. | 2009-09-22 |
|
| Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice. | 2009-06 |
|
| [Functional arginine-containing amino acid sequences in peptides and proteins]. | 2008-06-05 |
|
| Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC molecules. | 2008-03-19 |
|
| Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2. | 2008 |
|
| Vascular effects, angiotensin I-converting enzyme (ACE)-inhibitory activity, and antihypertensive properties of peptides derived from egg white. | 2007-12-26 |
|
| The pH-dependent conformational states of kyotorphin: a constant-pH molecular dynamics study. | 2007-03-15 |
|
| Strategies for enhanced drug delivery to the central nervous system. | 2007-02-20 |
|
| Separation and determination of l-tyrosine and its metabolites by capillary zone electrophoresis with a wall-jet amperometric detection. | 2006-12-15 |
|
| Chiral recognition of D-kyotorphin by lipidic membranes: relevance toward improved analgesic efficiency. | 2006-07 |
|
| Conformational and orientational guidance of the analgesic dipeptide kyotorphin induced by lipidic membranes: putative correlation toward receptor docking. | 2006-02-23 |
|
| Kyotorphin suppresses proliferation and Ca2+ signaling in brown preadipocytes. | 2006-02 |
|
| Kyotorphin has a novel action on rat cardiac muscle. | 2006-01-20 |
|
| Contributions of electromigration and electroosmosis to peptide iontophoresis across intact and impaired skin. | 2005-11-28 |
|
| Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2. | 2005-08 |
|
| Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media. | 2005-04-05 |
|
| [A conformational study of kiotorphin and its biologically active analogue]. | 2005-03-12 |
|
| A microtiter plate assay for the determination of the synthetic activity of protease. | 2004-10-01 |
|
| Effect of D-arginine on antinociception induced by kyotorphin, Tyr-cav, L-cav and Tyr(Cl2)-cav in rats. | 2004-06 |
|
| Morphofunctional changes in Mauthner neurons during exposure to the neuropeptide kyotorphin. | 2004-05 |
|
| Functional characterization of brain peptide transporter in rat cerebral cortex: identification of the high-affinity type H+/peptide transporter PEPT2. | 2004-01-30 |
|
| Effects of kyotorphin and analogues on nociception and pentylenetetrazole seizures. | 2004 |
|
| [Development of postresuscitation morphological changes of hippocampal and cerebellar neurons: common regularities and specific features]. | 2003-07-04 |
|
| [Therapy of postresuscitation behavioral disorders with mexidol and kyotorphin]. | 2003-03-04 |
|
| Involvement of nitric oxide in the nociception of kyotorphin, TYR-CAV and MIF-s analogues in the rat spinal cord. | 2003-03 |
|
| Safety of a new extensively hydrolysed formula in children with cow's milk protein allergy: a double blind crossover study. | 2002-10-14 |
|
| The spinal antinociceptive effect of kyotorphin in mice: involvement of the descending noradrenergic and serotonergic systems. | 2002-08-30 |
|
| Opioid peptides inhibit excitatory but not inhibitory synaptic transmission in the rat dorsal motor nucleus of the vagus. | 2002-04-15 |
|
| Blockade of the antinociceptive effect of spinally administered kyotorphin by naltrindole in mice. | 2002-04-05 |
|
| New insights in Adipokinetic Hormone (AKH) precursor processing in Locusta migratoria obtained by capillary liquid chromatography-tandem mass spectrometry. | 2002-04 |
|
| [Morpho-functional changes of Mauthner neurons after treatment with neuropeptide kyotorphin ]. | 2002 |
|
| Functional and molecular characterization of a peptide transporter in the rat PC12 neuroendocrine cell line. | 2001-11-23 |
|
| Synthesis and analgesic effects of kyotorphin-steroid linkers. | 2001-11 |
|
| PEPT2-mediated uptake of neuropeptides in rat choroid plexus. | 2001-06 |
|
| Conjugation with L-Glutamate for in vivo brain drug delivery. | 2001 |
|
| [Effect of kyotorphin on the seizure activity induced by kainic acid during picrotoxin kindling in rats]. | 1998-06-05 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:02:02 GMT 2025
by
admin
on
Mon Mar 31 19:02:02 GMT 2025
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| Record UNII |
02N30CW3X0
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| Record Status |
Validated (UNII)
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| Record Version |
|
-
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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58184
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123804
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70904-56-2
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KYOTORPHIN
Created by
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DTXSID40221136
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C019448
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02N30CW3X0
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17537
Created by
admin on Mon Mar 31 19:02:02 GMT 2025 , Edited by admin on Mon Mar 31 19:02:02 GMT 2025
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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TRANSPORTER -> INHIBITOR |
