U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C9H12N5O4.Na
Molecular Weight 277.2124
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GANCICLOVIR SODIUM

SMILES

[Na+].NC1=NC2=C(N=CN2COC(CO)CO)C(=O)[N-]1

InChI

InChIKey=JJICLMJFIKGAAU-UHFFFAOYSA-M
InChI=1S/C9H13N5O4.Na/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17);/q;+1/p-1

HIDE SMILES / InChI
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C9H12N5O4
Molecular Weight 254.2227
Charge -1
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/monograph/valganciclovir-hydrochloride.html | http://www.rxlist.com/valcyte-drug/indications-dosage.htm

There is no information in the literature about pharmacological and biological application of definite isomer: R of valganciclovir. However, is known, that valganciclovir, existing, as a mixture of R and S diasteriomers, is the active ingredient in Valcyte, which is used as an antiviral medication given to patients who have a high chance of developing cytomegalovirus (CMV) disease after receiving a heart, kidney, or kidney-pancreas transplant. It was proposed, that stable aqueous solutions of valganciclovir can be prepared in aqueous solutions at acidic pHs but these solutions will exist as a mixture of isomers: R and S

CNS Activity

Originator

Approval Year

1989
121
Targets

Targets

Primary TargetPharmacologyConditionPotency
DNA polymerase catalytic subunit
12
Target ID: P08546
Gene ID: NA
Gene Symbol: UL54
Target Organism: Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Antagonist
2760
Inhibitor
8228
 0.08 µM [EC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8360
ZIRGAN

Approved Use

ZIRGAN is a topical ophthalmic antiviral that is indicated for the treatment of acute herpetic keratitis (dendritic ulcers).

Launch Date

8.1362878E11
Primary
Approved
8360
CYTOVENE

Approved Use

CYTOVENE-IV is indicated for the treatment of CMV retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). CYTOVENE-IV is also indicated for the prevention of CMV disease in transplant recipients at risk for CMV disease.

Launch Date

7.8805441E11
Primary
Approved
8360
VALCYTE

Approved Use

VALCYTE is indicated for the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)

Launch Date

9.8573759E11
Primary
Approved
8360
VALCYTE

Approved Use

VALCYTE is indicated for the prevention of CMV disease in kidney, heart, and kidney-pancreas transplant patients at high risk

Launch Date

9.8573759E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
4.8 mg/L
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/10747829
1 g 3 times / day multiple, oral
dose: 1 g
route of administration: Oral
experiment type: MULTIPLE
co-administered:
GANCICLOVIR plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
13.3 μg/mL
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/16737936
5 mg/kg single, intravenous
dose: 5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GANCICLOVIR plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
35.4 mg × h/L
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/10747829
1 g 3 times / day multiple, oral
dose: 1 g
route of administration: Oral
experiment type: MULTIPLE
co-administered:
GANCICLOVIR plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
53.8 μg × h/mL
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/16737936
5 mg/kg single, intravenous
dose: 5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GANCICLOVIR plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
5.2 h
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/16737936
5 mg/kg single, intravenous
dose: 5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GANCICLOVIR plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
1000 mg 6 times / day multiple, oral
Highest studied dose
Dose: 1000 mg, 6 times / day
Route: oral
Route: multiple
Dose: 1000 mg, 6 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
unhealthy, 37.4
n = 19
Health Status: unhealthy
Condition: AIDS
Age Group: 37.4
Population Size: 19
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
2000 mg 3 times / day multiple, oral
Highest studied dose
Dose: 2000 mg, 3 times / day
Route: oral
Route: multiple
Dose: 2000 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
unhealthy, 38.6
n = 50
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: 38.6
Population Size: 50
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
Other AEs: Neutropenia, Thrombocytopenia...
Other AEs:
Neutropenia (18%)
Thrombocytopenia (4%)
Anemia (severe, 4%)
Renal impairment (4%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
50 mg/kg 3 times / day multiple, oral
Highest studied dose
Dose: 50 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 50 mg/kg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11069232/
unhealthy, 7.4 years (range: 0.5-16.9 years)
n = 36
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: 7.4 years (range: 0.5-16.9 years)
Population Size: 36
Sources:
https://pubmed.ncbi.nlm.nih.gov/11069232/
Other AEs: Neutropenia...
Other AEs:
Neutropenia (22%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/11069232/
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Other AEs: Fever, Infection...
Other AEs:
Fever (48%)
Infection (13%)
Chills (10%)
Sepsis (15%)
Diarrhea (44%)
Anorexia (14%)
Vomiting (13%)
Leukopenia (41%)
Anemia (25%)
Thrombocytopenia (6%)
Neuropathy (9%)
Sweating (12%)
Pruritus (5%)
Catheter infection (9%)
Catheter sepsis (8%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
AEs

AEs

AESignificanceDosePopulation
Neutropenia 18%
2000 mg 3 times / day multiple, oral
Highest studied dose
Dose: 2000 mg, 3 times / day
Route: oral
Route: multiple
Dose: 2000 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
unhealthy, 38.6
n = 50
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: 38.6
Population Size: 50
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
Renal impairment 4%
2000 mg 3 times / day multiple, oral
Highest studied dose
Dose: 2000 mg, 3 times / day
Route: oral
Route: multiple
Dose: 2000 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
unhealthy, 38.6
n = 50
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: 38.6
Population Size: 50
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
Thrombocytopenia 4%
2000 mg 3 times / day multiple, oral
Highest studied dose
Dose: 2000 mg, 3 times / day
Route: oral
Route: multiple
Dose: 2000 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
unhealthy, 38.6
n = 50
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: 38.6
Population Size: 50
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
Anemia severe, 4%
2000 mg 3 times / day multiple, oral
Highest studied dose
Dose: 2000 mg, 3 times / day
Route: oral
Route: multiple
Dose: 2000 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
unhealthy, 38.6
n = 50
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: 38.6
Population Size: 50
Sources:
https://pubmed.ncbi.nlm.nih.gov/7769276/
Neutropenia 22%
50 mg/kg 3 times / day multiple, oral
Highest studied dose
Dose: 50 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 50 mg/kg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11069232/
unhealthy, 7.4 years (range: 0.5-16.9 years)
n = 36
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: 7.4 years (range: 0.5-16.9 years)
Population Size: 36
Sources:
https://pubmed.ncbi.nlm.nih.gov/11069232/
Chills 10%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Sweating 12%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Infection 13%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Vomiting 13%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Anorexia 14%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Sepsis 15%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Anemia 25%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Leukopenia 41%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Diarrhea 44%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Fever 48%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Pruritus 5%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Thrombocytopenia 6%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Catheter sepsis 8%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Catheter infection 9%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Neuropathy 9%
5 mg/kg 1 times / day multiple, intravenous
Recommended
Dose: 5 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 5 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
unhealthy, adult
n = 179
Health Status: unhealthy
Condition: CMV retinitis in HIV infection
Age Group: adult
Sex: M+F
Population Size: 179
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
supressor
9

OverviewOther

Other InhibitorOther SubstrateOther Inducer
MATE1
132

MATE2
94

OCT1
322

OAT1
320

OAT2
111

OAT3
333

OCT2
348

P-gp
1527

MRP4
75
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
OAT3
333
 no
OCT2
348
 no
MATE1
132
 yes
MATE2
94
 yes
MRP4
75
 yes
OAT1
320
 yes
OAT2
111
 yes
OCT1
322
 yes
P-gp
1527
 yes
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
hERG
1632
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:465284
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:465284
ChemicalBook
CB6203364
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB6203364
MolPort
MolPort-000-758-398
https://www.molport.com/shop/molecule-link/MolPort-000-758-398
MolPort
MolPort-002-507-301
https://www.molport.com/shop/molecule-link/MolPort-002-507-301
MolPort
MolPort-006-167-681
https://www.molport.com/shop/molecule-link/MolPort-006-167-681
Selleck Chemicals
ganciclovir
http://www.selleckchem.com/products/ganciclovir.html
ZINC
ZINC000000001505
http://zinc15.docking.org/substances/ZINC000000001505
eMolecules
31410312
https://www.emolecules.com/cgi-bin/more?vid=31410312
eMolecules
538661
https://www.emolecules.com/cgi-bin/more?vid=538661
PubMed

PubMed

TitleDatePubMed
Guanosine analogues as anti-herpesvirus agents.
2000 Oct-Dec
Recent advances in imaging endogenous or transferred gene expression utilizing radionuclide technologies in living subjects: applications to breast cancer.
2001
Suicide gene therapy for human oral squamous cell carcinoma cell lines with adeno-associated virus vector.
2001 Apr
Intravitreal pharmacokinetics and retinal concentrations of ganciclovir and foscarnet after intravitreal administration in rabbits.
2001 Apr
Cytological monitoring of peripheral blood, bronchoalveolar lavage fluid, and transbronchial biopsy specimens during acute rejection and cytomegalovirus infection in lung and heart--lung allograft recipients.
2001 Apr
Suspension of anticytomegalovirus maintenance therapy following immune recovery due to highly active antiretroviral therapy.
2001 Apr
Risk for cytomegalovirus disease in patients receiving polymerase chain reaction-based preemptive antiviral therapy after allogeneic stem cell transplantation depends on transplantation modality.
2001 Apr 1
A time to live, a time to die.
2001 Apr 15
Adenoviral-mediated gene therapy for thyroid carcinoma using thymidine kinase controlled by thyroglobulin promoter demonstrates high specificity and low toxicity.
2001 Feb
Gamma-rays enhance rAAV-mediated transgene expression and cytocidal effect of AAV-HSVtk/ganciclovir on cancer cells.
2001 Feb
Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase-mediated suicide gene therapy.
2001 Feb
Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis.
2001 Feb
Effect of the complexation with cyclodextrins on the in vitro antiviral activity of ganciclovir against human cytomegalovirus.
2001 Feb
Genetic risks of antiviral nucleoside analogues--a survey.
2001 Feb
Failure of cidofovir to reduce CMV-antigenemia in a child transplanted from a matched unrelated donor.
2001 Feb
Coexistent cutaneous Aspergillus and cytomegalovirus infection in a liver transplant recipient.
2001 Feb
Selective killing of human immunodeficiency virus-infected cells by targeted gene transfer and inducible gene expression using a recombinant human immunodeficiency virus vector.
2001 Feb 10
Stimulation of intercellular communication of poor-communicating cells by gap-junction-competent cells enhances the HSV-TK/GCV bystander effect in vitro.
2001 Feb 15
Ovarian epithelial cell lineage-specific gene expression using the promoter of a retrovirus-like element.
2001 Feb 15
Coexpression of the partial androgen receptor enhances the efficacy of prostate-specific antigen promoter-driven suicide gene therapy for prostate cancer cells at low testosterone concentrations.
2001 Feb 15
A tightly regulated immortalized human fetal hepatocyte cell line to develop a bioartificial liver.
2001 Feb-Mar
Meta-analysis of prophylaxis of CMV disease in solid organ transplantation: is Ganciclovir a superior agent to Acyclovir?
2001 Feb-Mar
Preemptive ganciclovir for CMV viremia in liver transplantation.
2001 Feb-Mar
Prophylactic antiviral therapy in CMV high-risk liver transplant recipients.
2001 Feb-Mar
Is preemptive therapy for CMV infection following liver transplantation superior to symptom-triggered treatment?
2001 Feb-Mar
Cytomegalovirus infection-enhanced chronic rejection in the rat is prevented by antiviral prophylaxis.
2001 Feb-Mar
Ganciclovir prophylaxis for cytomegalovirus infection in simultaneous kidney-pancreas transplant recipients receiving tacrolimus, mycophenolate mofetil, and prednisone.
2001 Feb-Mar
CMV in kidney transplants in the tacrolimus-mycophenolate era.
2001 Feb-Mar
Rat glioma cell death induced by cationic liposome-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment.
2001 Jan
Epstein-Barr virus encephalitis in a renal allograft recipient diagnosed by polymerase chain reaction on cerebrospinal fluid and successfully treated with ganciclovir.
2001 Jan
Antiviral drugs in chronic hepatitis B: review and meta-analysis.
2001 Jan
[Perspectives on postgenome medicine: Gene therapy for brain tumors].
2001 Jan
In vitro effects of antiviral agents on human keratocytes.
2001 Jan
Management of complications associated with totally implantable ports in patients with AIDS.
2001 Jan
Cytomegalovirus hemorrhagic gastritis.
2001 Jan
Retrovector encoding a green fluorescent protein-herpes simplex virus thymidine kinase fusion protein serves as a versatile suicide/reporter for cell and gene therapy applications.
2001 Jan 1
Disseminated cytomegalovirus disease in hosts without acquired immunodeficiency syndrome and without an organ transplant.
2001 Jan 15
Virological, clinical, and ophthalmologic features of cytomegalovirus retinitis after hematopoietic stem cell transplantation.
2001 Jan 15
Fatal primary infection due to human herpesvirus 6 variant A in a renal transplant recipient.
2001 Jan 27
Toxic megacolon: remember cytomegalovirus.
2001 Mar
Cytomegalovirus colitis complicating ulcerative colitis in the steroid-naive patient.
2001 Mar
Prevalence of cytomegalovirus infection in severe refractory ulcerative and Crohn's colitis.
2001 Mar
The real danger of lamivudine-resistant hepatitis B virus infection in the immunocompromised host.
2001 Mar
High-dose intravitreal ganciclovir and foscarnet for cytomegalovirus retinitis.
2001 Mar
Frosted branch angiitis in a child with HIV infection.
2001 Mar
New developments in the management of cytomegalovirus infection and disease after renal transplantation.
2001 Mar
Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model.
2001 Mar 1
Preevaluation of clinical trial data: the case of preemptive cytomegalovirus therapy in patients with human immunodeficiency virus.
2001 Mar 1
Preemptive therapy versus universal prophylaxis with ganciclovir for cytomegalovirus in solid organ transplant recipients.
2001 Mar 1
Prophylaxis for CMV should not now replace pre-emptive therapy in solid organ transplantation.
2001 Mar-Apr
Patents

Patents

04355032
7
04609661
7
04803271
7
JP2000514093A
7
JP2002541233A
397
JP2004016051A
7
JP2007508039A
113
JP2011525180A
178
JP4733833B2
7
JP4758474B2
86
JPH0841061A
7
JPH0853452A
7
JPS57203086A
7
US20120121700 A1
7
US8586738 B2
7
US8889109 B2
7

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Ganciclovir can be used as ophthalmic gel 1 drop in the affected eye 5 times per day in patients with acute herpetic keratitis.
5 mg/kg every 12 hours (given intravenously at a constant rate over 1 hour) (induction treatment) and 5 mg/kg given as a constant-rate intravenous infusion over 1 hour once daily, 7 days per week, or 6 mg/kg once daily, 5 days per week (maintenance treatment).
Route of Administration: Intravenous
In Vitro Use Guide
Curator's Comment: The median concentration of ganciclovir that inhibits CMV replication (IC50) in vitro (laboratory strains or clinical isolates) has ranged from 0.02 to 3.48 ug/mL.
IC50 is from 0.02 to 3.48 ug/mL
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:40:26 UTC 2023
Edited
by admin
on Wed Jul 05 22:40:26 UTC 2023
Record UNII
02L083W284
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GANCICLOVIR SODIUM
MART.   ORANGE BOOK   USAN   WHO-DD  
USAN  
Official Name English
GANCICLOVIR SODIUM [MART.]
Common Name English
Ganciclovir sodium [WHO-DD]
Common Name English
GANCICLOVIR (AS SODIUM) [VANDF]
Common Name English
GANCICLOVIR SODIUM SALT [MI]
Common Name English
RS-21592 SODIUM
Code English
CYTOVENE IV
Brand Name English
9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine, monosodium salt
Common Name English
CYTOVENE
Brand Name English
GANCICLOVIR SODIUM SALT
MI  
Common Name English
GANCICLOVIR SODIUM [ORANGE BOOK]
Common Name English
6H-PURIN-6-ONE, 2-AMINO-1,9-DIHYDRO-9-((2-HYDROXY-1-(HYDROXYMETHYL)ETHOXY)METHYL)-, MONOSODIUM SALT
Common Name English
GANCICLOVIR SODIUM [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1556
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
NCI_THESAURUS C29575
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
NCI_THESAURUS C281
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
FDA ORPHAN DRUG 7985
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
Code System Code Type Description
EVMPD
SUB02312MIG
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
WIKIPEDIA
Ganciclovir sodium
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
EPA CompTox
DTXSID20883175
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
RXCUI
82131
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY RxNorm
USAN
Z-46
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
ChEMBL
CHEMBL182
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
DRUG BANK
DBSALT000309
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
DAILYMED
02L083W284
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
PUBCHEM
23700083
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
SMS_ID
100000089399
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
CAS
107910-75-8
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
FDA UNII
02L083W284
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
NCI_THESAURUS
C1588
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY
MERCK INDEX
M5663
Created by admin on Wed Jul 05 22:40:26 UTC 2023 , Edited by admin on Wed Jul 05 22:40:26 UTC 2023
PRIMARY Merck Index
Related Record Type Details
Structure of GANCICLOVIR
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of GANCICLOVIR
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