ATESIDORSEN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Tue Apr 01 20:35:09 GMT 2025` Edited by `admin` on `Tue Apr 01 20:35:09 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Type	P0LYNUCLEOTIDE
Record UNII	015582E098
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ATESIDORSEN

Official Name

English

atesidorsen [INN]

Preferred Name

English

ATESIDORSEN [USAN]

Common Name

English

(ALL-P-AMBO)-2'-O-(2-METHOXYETHYL)-5-METHYL-P-THIOURIDYLYL-(3'->5')-2'-O-(2-METHOXYETHYL)-5-METHYL-P-THIOCYTIDYLYL-(3'->5')-2'-O-(2-METHOXYETHYL)-P-THIOADENYLYL-(3'->5')-2'-O-(2-METHOXYETHYL)-P-THIOGUANYLYL-(3'->5')-2'-O-(2-METHOXYETHYL)-P-THIOGUANYLYL-(

Systematic Name

English

DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RG-G-M5C-A-T-T-M5C-T-T-T-M5C-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C171735

Created by admin on Tue Apr 01 20:35:09 GMT 2025 , Edited by admin on Tue Apr 01 20:35:09 GMT 2025

PRIMARY

INN

10520

Created by admin on Tue Apr 01 20:35:09 GMT 2025 , Edited by admin on Tue Apr 01 20:35:09 GMT 2025

PRIMARY

CAS

872063-57-5

Created by admin on Tue Apr 01 20:35:09 GMT 2025 , Edited by admin on Tue Apr 01 20:35:09 GMT 2025

PRIMARY

SMS_ID

300000008878

Created by admin on Tue Apr 01 20:35:09 GMT 2025 , Edited by admin on Tue Apr 01 20:35:09 GMT 2025

PRIMARY

USAN

DE-54

Created by admin on Tue Apr 01 20:35:09 GMT 2025 , Edited by admin on Tue Apr 01 20:35:09 GMT 2025

PRIMARY

FDA UNII

015582E098

Created by admin on Tue Apr 01 20:35:09 GMT 2025 , Edited by admin on Tue Apr 01 20:35:09 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_6-1_15	10 / 20
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_20	19 / 19

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Related Record Type Details

015582E098

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE SUBSTITUTION	[1_7] [1_11] [1_15]		C		5-METHYLDEOXYCYTIDINE	B200GV71QM
NUCLEOSIDE SUBSTITUTION	[1_1] [1_18] [1_19]		U		2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE	9Q36I4D9VB
NUCLEOSIDE SUBSTITUTION	[1_2] [1_16] [1_20]		C		2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE	AOQ54IZZ6J