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Details

Stereochemistry ABSOLUTE
Molecular Formula C33H34N4O6
Molecular Weight 582.6475
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AZELNIDIPINE, (R)-

SMILES

CC(C)OC(=O)C1=C(C)NC(=C([C@]1([H])c2cccc(c2)N(=O)=O)C(=O)OC3CN(C3)C(c4ccccc4)c5ccccc5)N

InChI

InChIKey=ZKFQEACEUNWPMT-MUUNZHRXSA-N
InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3/t28-/m1/s1

HIDE SMILES / InChI

Molecular Formula C33H34N4O6
Molecular Weight 582.6475
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Calblock

Approved Use

As a calcium channel antagonist, this medicine relaxes blood vessels in order to lower blood pressure. It is usually used to treat hypertension.

Launch Date

1043971200000
PubMed

PubMed

TitleDatePubMed
Enantioselective determination of azelnidipine in human plasma using liquid chromatography-tandem mass spectrometry.
2007 Jun 1
Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence.
2012 Feb
Clinical use of azelnidipine in the treatment of hypertension in Chinese patients.
2015
Patents

Sample Use Guides

The normal dose for an adult is 8-16 mg of azelnidipine once daily, taken orally after breakfast. The maximum dosage is 16 mg/day. The initial dosage is to be 8 mg/day or less, to be adjusted as symptoms are monitored, up to 16 mg daily.
Route of Administration: Oral
(R)-(-)-azelnidipine (100 nM) reduces the TGF-b1- or Ang
Substance Class Chemical
Created
by admin
on Fri Jun 25 22:46:49 UTC 2021
Edited
by admin
on Fri Jun 25 22:46:49 UTC 2021
Record UNII
0089IC5K88
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AZELNIDIPINE, (R)-
Common Name English
(R)-AZELNIDIPINE
Common Name English
(R)-(-)-AZELNIDIPINE
Common Name English
3,5-PYRIDINEDICARBOXYLIC ACID, 2-AMINO-1,4-DIHYDRO-6-METHYL-4-(3-NITROPHENYL)-, 3-(1-(DIPHENYLMETHYL)-3-AZETIDINYL) 5-(1-METHYLETHYL) ESTER, (4R)-
Systematic Name English
Code System Code Type Description
CAS
722455-08-5
Created by admin on Fri Jun 25 22:46:49 UTC 2021 , Edited by admin on Fri Jun 25 22:46:49 UTC 2021
PRIMARY
PUBCHEM
9873077
Created by admin on Fri Jun 25 22:46:49 UTC 2021 , Edited by admin on Fri Jun 25 22:46:49 UTC 2021
PRIMARY
FDA UNII
0089IC5K88
Created by admin on Fri Jun 25 22:46:49 UTC 2021 , Edited by admin on Fri Jun 25 22:46:49 UTC 2021
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER