U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C19H20O10
Molecular Weight 408.3561
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of KHELLOSIDE

SMILES

COC1=C2C=COC2=CC3=C1C(=O)C=C(CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)O3

InChI

InChIKey=SJRACCTZSAUMGO-WIMVFMHDSA-N
InChI=1S/C19H20O10/c1-25-18-9-2-3-26-11(9)5-12-14(18)10(21)4-8(28-12)7-27-19-17(24)16(23)15(22)13(6-20)29-19/h2-5,13,15-17,19-20,22-24H,6-7H2,1H3/t13-,15-,16+,17-,19-/m1/s1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including DOI: 10.1002/aoc.151, p 339, Retrived from https://books.google.es/books?id=vVCGAwAAQBAJ&pg=PA339&lpg=PA339&dq=angina+pectoris+khellol+glucoside&source=bl&ots=4XAYnaL5Bb&sig=12nesrI70kvyvT4dPdGlhXvoZJ4&hl=ru&sa=X&ved=0ahUKEwicjLjsjbPQAhVo6IMKHV6aBMgQ6AEILDAD#v=onepage&q=angina%20pectoris%20khellol%20glucoside&f=false

Khelloside is a component of Ammi visnaga L. fruits extract, a medicine which is used in Egypt as remedy for the treatment of kidney stones. Khelloside itself exhibits a wide variety of biological activities including anti-anginal, antiatherosclerotic, lipid altering, antipyretic and spasmolytic. It was clinically tested for asthma, angina pectoris and skin disease, however its develoment seems to be discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
[Clinical use of khellol-glucoside].
1954 Aug 15
[Treatment of angina pectoris with khellol-glucoside].
1957 Apr 21
Hypocholesterolemic effect of khellin and khelloside in female cynomolgus monkeys.
1985

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Studies on monkeys.
The oral dose of 20 mg/kg was given once daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
KHELLOSIDE
INN  
INN  
Official Name English
NSC-82907
Code English
khelloside [INN]
Common Name English
KHELLENIN
Common Name English
KHELLOLGLUCOSIDE
Common Name English
KHELLOL GLUCOSIDE [MI]
Common Name English
7-HYDROXYMETHYL-4-METHOXY-5H-FURO(3,2-G)(1)BENZOPYRAN-5-ONE GLUCOSIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29703
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C83858
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY
EPA CompTox
DTXSID40878402
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY
PUBCHEM
441966
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY
MERCK INDEX
m254
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY Merck Index
CAS
17226-75-4
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
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MESH
C047312
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY
INN
191
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY
FDA UNII
ZX4FRZ5WJP
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY
EVMPD
SUB08381MIG
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY
ChEMBL
CHEMBL2107506
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY
ECHA (EC/EINECS)
241-263-3
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY
NSC
82907
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY
SMS_ID
100000083099
Created by admin on Fri Dec 15 15:08:39 GMT 2023 , Edited by admin on Fri Dec 15 15:08:39 GMT 2023
PRIMARY