REDAPORFIN

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C48H38F8N8O8S4
Molecular Weight	1135.111
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNS(=O)(=O)C1=CC=C(F)C(=C1F)C2=C3CCC(=N3)C(=C4NC(C=C4)=C(C5=NC(CC5)=C(C6=CC=C2N6)C7=C(F)C(=CC=C7F)S(=O)(=O)NC)C8=C(F)C(=CC=C8F)S(=O)(=O)NC)C9=C(F)C(=CC=C9F)S(=O)(=O)NC

InChI

InChIKey=CKRVBMUJCFKRND-ZXWMLXKTSA-N

InChI=1S/C48H38F8N8O8S4/c1-57-73(65,66)33-17-5-21(49)37(45(33)53)41-25-9-11-27(61-25)42(38-22(50)6-18-34(46(38)54)74(67,68)58-2)29-13-15-31(63-29)44(40-24(52)8-20-36(48(40)56)76(71,72)60-4)32-16-14-30(64-32)43(28-12-10-26(41)62-28)39-23(51)7-19-35(47(39)55)75(69,70)59-3/h5-9,11,14,16-20,57-61,64H,10,12-13,15H2,1-4H3/b41-25+,41-26+,42-27+,42-29+,43-28+,43-30+,44-31+,44-32+

HIDE SMILES / InChI

Description
Sources: https://www.cancer.gov/publications/dictionaries/cancer-drug/def/photosensitizer-luz-11 | https://www.luzitin.pt/luz11.php

F2BMET (redaporfin or LUZ11), a fluorinated sulfonamide bacteriochlorin, is photosensitizer, with antineoplastic activity upon photodynamic therapy. F2BMET is a third generation bacteriochlorin molecule which has a greater ability to absorb light and convert it into active molecular species (reactive oxygen species), better depth penetration, and improved efficacy. F2BMET has promising Phase I/IIA POC clinical data in advanced head and neck cancer which clearly reinforces the favorable results from non-clinical studies. It has received Orphan Drug Designation (ODD) from EMA in Europe for Biliary tract cancer.

Originator

Approval Year

PubMed

Title	Date	PubMed
Design of Pluronic-Based Formulation for Enhanced Redaporfin-Photodynamic Therapy against Pigmented Melanoma.	2016-08-31	27492026
The role of strong hypoxia in tumors after treatment in the outcome of bacteriochlorin-based photodynamic therapy.	2014-08	24835769

Name

Type

Language

REDAPORFIN

Official Name

English

redaporfin [INN]

Preferred Name

English

3,3',3'',3'''-(7,8,17,18-TETRAHYDROPORPHYRIN-5,10,15,20-TETRAYL)TETRAKIS(2,4-DIFLUORO-N-METHYLBENZENESULFONAMIDE)

Systematic Name

English

BENZENESULFONAMIDE, 3,3',3'',3'''-(7,8,17,18-TETRAHYDRO-21H,23H-PORPHINE-5,10,15,20-TETRAYL)TETRAKIS(2,4-DIFLUORO-N-METHYL-

Systematic Name

English

Redaporfin [WHO-DD]

Common Name

English

F2BMET

Common Name

English

LUZ-11

Code

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/15/1470