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Details

Stereochemistry ACHIRAL
Molecular Formula CN2.Ca
Molecular Weight 80.102
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CALCIUM CARBIMIDE

SMILES

[Ca++].[N--]C#N

InChI

InChIKey=MYFXBBAEXORJNB-UHFFFAOYSA-N
InChI=1S/CN2.Ca/c2-1-3;/q-2;+2

HIDE SMILES / InChI

Description

Calcium carbimide, a disulfiram-like drug was marketed in some countries, e.g., in Australia, in South Africa, in the Netherlands, in the United Kingdom, and in Canada (under the brand name Temposil) for the treatment of chronic alcoholism. The drug produced physiological changes after ethanol consumption by means of interfering with the normal metabolism of alcohol. Carbimide was a competitive inhibitor of the hepatic aldehyde-NAD oxidoreductase dehydrogenase. As a result, it was unpleasant further drinking. In 2006 was published an article where was described the hepatotoxicity effect of the drug and mentioned that had to be reassessment the role of the compound in the management of alcohol dependence.

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
A single dose of 50 mg of citrated calcium carbimide will sensitize an individual to alcohol.
Route of Administration: Oral