Intismeran Autogene

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Name

Type

Language

MRNA4157

Preferred Name

English

Intismeran Autogene

Official Name

English

intismeran autogene [INN]

Common Name

English

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Gm)-capped all uridine?N1-methylpseudouridine-substituted patient-specific neoantigen-specifying plus 5?- and 3?-untranslated flanking region-containing poly(A)-tailed messenger mRNA-4157), inner salt

Common Name

English

messenger RNA (mRNA), 5'-capped, encoding a codon-optimized patient specific concatemer of up to 34 neoantigens designed specifically to each individual patient's tumor mutanome and human leukocyte antigen (HLA) type, further optimized by two additional

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C146813

Created by admin on Wed Apr 02 08:02:47 GMT 2025 , Edited by admin on Wed Apr 02 08:02:47 GMT 2025

PRIMARY

INN

13221

Created by admin on Wed Apr 02 08:02:47 GMT 2025 , Edited by admin on Wed Apr 02 08:02:47 GMT 2025

PRIMARY

SMS_ID

300000047919

Created by admin on Wed Apr 02 08:02:47 GMT 2025 , Edited by admin on Wed Apr 02 08:02:47 GMT 2025

PRIMARY

CAS

2931460-85-2

Created by admin on Wed Apr 02 08:02:47 GMT 2025 , Edited by admin on Wed Apr 02 08:02:47 GMT 2025

PRIMARY

FDA UNII

ZG6U44T8SG

Created by admin on Wed Apr 02 08:02:47 GMT 2025 , Edited by admin on Wed Apr 02 08:02:47 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_2125	2125 / 2125

Linkage	Site Range	Site Count
Phosphate	1_2-1_2125	2124 / 2124

ACTIVE MOIETY


					ZG6U44T8SG

Intismeran Autogene