MEBANAZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C8H12N2
Molecular Weight	136.1943
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(NN)C1=CC=CC=C1

InChI

InChIKey=HHRZAEJMHSGZNP-UHFFFAOYSA-N

InChI=1S/C8H12N2/c1-7(10-9)8-5-3-2-4-6-8/h2-7,10H,9H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25174932 | https://www.ncbi.nlm.nih.gov/pubmed/5320546 | https://www.ncbi.nlm.nih.gov/pubmed/4392571

Mebanazine is an inhibitor of monoamine oxidase. It was introduced in the 1960s for the treatment of depression and was marketed under trade name Actomol. The drug was withdrawn from the market due to hepatotoxicity. In addition to its antidepressant effect, the drug was found to possess an anorexic action and in animal models, it potentiated the hypoglycemic response to insulin and delayed the recovery of blood glucose levels to normal.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Monoamine oxidase 32 Target ID: CHEMBL2095205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5889715	Inhibitor 8297

PubMed

Title	Date	PubMed
A controlled trial of mebanazine ('Actomol') in depression.	1965 Nov	5320546
A preliminary trial of mebanazine in depressive states.	1965 Nov-Dec	5327282
Clinical trial of mebanazine--a new monoamine oxidase inhibitor.	1965 Sep	5889715

Name

Type

Language

MEBANAZINE

Official Name

English

Mebanazine [WHO-DD]

Common Name

English

HYDRAZINE, (1-PHENYLETHYL)-

Systematic Name

English

(1-PHENYLETHYL)HYDRAZINE

Systematic Name

English

mebanazine [INN]

Common Name

English

ACTAMOL

Brand Name

English

.ALPHA.-METHYLBENZYLHYDRAZINE

Systematic Name

English

MEBANAZINE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C667