Details
Stereochemistry | RACEMIC |
Molecular Formula | C8H12N2 |
Molecular Weight | 136.1943 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(NN)C1=CC=CC=C1
InChI
InChIKey=HHRZAEJMHSGZNP-UHFFFAOYSA-N
InChI=1S/C8H12N2/c1-7(10-9)8-5-3-2-4-6-8/h2-7,10H,9H2,1H3
Mebanazine is an inhibitor of monoamine oxidase. It was introduced in the 1960s for the treatment of depression and was marketed under trade name Actomol. The drug was withdrawn from the market due to hepatotoxicity. In addition to its antidepressant effect, the drug was found to possess an anorexic action and in animal models, it potentiated the hypoglycemic response to insulin and delayed the recovery of blood glucose levels to normal.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2095205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5889715 |
PubMed
Title | Date | PubMed |
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A controlled trial of mebanazine ('Actomol') in depression. | 1965 Nov |
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A preliminary trial of mebanazine in depressive states. | 1965 Nov-Dec |
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Clinical trial of mebanazine--a new monoamine oxidase inhibitor. | 1965 Sep |
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Contribution of sleep research to the development of new antidepressants. | 2005 |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C667
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CHEMBL1909283
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C80969
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SUB08659MIG
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C004343
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4865
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Mebanazine
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ACTIVE MOIETY