U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H15ClN2O3S
Molecular Weight 350.82
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULOFENUR

SMILES

ClC1=CC=C(NC(=O)NS(=O)(=O)C2=CC3=C(CCC3)C=C2)C=C1

InChI

InChIKey=JQJSFAJISYZPER-UHFFFAOYSA-N
InChI=1S/C16H15ClN2O3S/c17-13-5-7-14(8-6-13)18-16(20)19-23(21,22)15-9-4-11-2-1-3-12(11)10-15/h4-10H,1-3H2,(H2,18,19,20)

HIDE SMILES / InChI
Sulofenur is an orally active diarylsulfonylurea derivative patented by American pharmaceutical company Eli Lilly and Co. as an antitumor agent. In preclinical studies, Sulofenur exhibits significant activity against advanced colon adenocarcinoma xenografts intrinsically resistant to virtually all standard chemotherapeutic agents and also had very significant activity against several pediatric tumors grown as xenografts. Clinically, Sulofenur was disappointing, and although some responses were reported in phase I trials this was not confirmed for ovarian cancer in the phase II setting. Toxicity in man was due mainly to methemoglobinemia and anemia, which limited the concentrations of drug that could be achieved to levels well below those shown to elicit a therapeutic response in the xenograft models.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

700 mg/m2 for 14 days every 3 weeks
Route of Administration: Oral
Name Type Language
SULOFENUR
INN   MART.   USAN  
INN   USAN  
Official Name English
LY-186641
Code English
SULOFENUR [USAN]
Common Name English
sulofenur [INN]
Common Name English
LY186641
Code English
SULOFENUR [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2186
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID20149208
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY
PUBCHEM
60417
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY
FDA UNII
Z45N070N3S
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY
USAN
AA-11
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY
CAS
110311-27-8
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY
ChEMBL
CHEMBL7643
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY
SMS_ID
100000082975
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY
MESH
C058179
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY
INN
6607
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY
NCI_THESAURUS
C1432
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY
EVMPD
SUB10753MIG
Created by admin on Fri Dec 15 15:09:48 GMT 2023 , Edited by admin on Fri Dec 15 15:09:48 GMT 2023
PRIMARY