Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H8ClO.Na |
| Molecular Weight | 178.591 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CC1=CC([O-])=CC(C)=C1Cl
InChI
InChIKey=IUJGTVGVLAYVKG-UHFFFAOYSA-M
InChI=1S/C8H9ClO.Na/c1-5-3-7(10)4-6(2)8(5)9;/h3-4,10H,1-2H3;/q;+1/p-1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.uwlax.edu/urc/JUR-online/PDF/2000/Koecher_and_Krenke.pdf
Curator's Comment: description was created based on several sources, including
https://www.uwlax.edu/urc/JUR-online/PDF/2000/Koecher_and_Krenke.pdf
Chloroxylenol is used as a preservative in cooling fluids, cosmetics, topical medications, urinary antiseptics and metal working fluids. Products containing Chloroxylenol are used for cleaning and disinfecting wounds, abrasions and abscesses, for minor cuts and scratches, insect bites, burns, inflammation of the skin. It is also found in hair conditioners, toilet cleaners, deodorants, soaps and paste. New use cases continue to be identified. Chloroxylenol has been shown to be effective at reducing the number of pathogenic bacteria in clinical environments. Chloroxylenol has been reviewed and is permitted for use within the European Union (EU) in cosmetic products and is also permitted for use in a number of topical pharmaceutical products as licensed by the UK Medicines and Health Regulatory Agency. Chloroxylenol could cause mild skin irritation in some individuals, or cause an allergic reaction in others. Developed in Europe in the 1920s and used in the United States since the 1950s, Chloroxylenol is one of the most mature antimicrobial agents
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Female condom reuse in Lusaka, Zambia: evidence from 12 cases. | 2001 Dec |
|
| [Determination of 4-chloro-3,5-dimethyl phenol in antiseptics and synthetic products by scanning thin-layer chromatography]. | 2001 Jul |
|
| Evaluation of diazotized 4-amino-3,5-dinitrobenzoic acid (ADBA) as a new derivatizing reagent. | 2001 Sep |
|
| Comparative susceptibility of resident and transient hand bacteria to para-chloro-meta-xylenol and triclosan. | 2002 |
|
| Sonochemical degradation of aromatic organic pollutants. | 2002 |
|
| Toxicological screening for drugs of abuse in samples adulterated with household chemicals. | 2002 Jul |
|
| Chloroxylenol- and triclosan-tolerant bacteria from industrial sources. | 2002 Nov |
|
| Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America. | 2002 Oct 25 |
|
| Contamination of toothbrush at different time intervals and effectiveness of various disinfecting solutions in reducing the contamination of toothbrush. | 2002 Sep |
|
| Comparison of chloroxylenol 0.5% plus salicylic acid 2% cream and benzoyl peroxide 5% gel in the treatment of acne vulgaris: a randomized double-blind study. | 2003 |
|
| Allergenicity evaluation of p-chloro-m-cresol and p-chloro-m-xylenol by non-radioactive murine local lymph-node assay and multiple-dose guinea pig maximization test. | 2003 Aug 28 |
|
| The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance. | 2003 Feb |
|
| Use of the 'ex vivo' test to study long-term bacterial survival on human skin and their sensitivity to antisepsis. | 2004 |
|
| Comparative analysis of antibiotic and antimicrobial biocide susceptibility data in clinical isolates of methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa between 1989 and 2000. | 2004 |
|
| Identification of estrogenic compounds in fish bile using bioassay-directed fractionation. | 2004 Dec 1 |
|
| Stridor after ingestion of dettol and domestos. | 2004 Feb |
|
| An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity. | 2004 Jan |
|
| [Simultaneous determination of chloroxylenol, trilocarban and triclosan in cosmetics or household products by reversed-phase high performance liquid chromatography]. | 2004 Nov |
|
| Comparison of two in vivo and two ex vivo tests to assess the antibacterial activity of several antiseptics. | 2004 Oct |
|
| [Efficacy of biocides against hospital isolates of Staphylococcus sensitive and resistant to methicillin, in the province of Buenos Aires, Argentina]. | 2004 Sep |
|
| Contact sensitivity to preservatives in Turkey. | 2005 Jun |
|
| Efficacy of surgical preparation solutions in foot and ankle surgery. | 2005 May |
|
| The effects of biocides (antiseptics and disinfectants) on the endospores of Rhinosporidium seeberi. | 2006 Apr |
|
| Antifungal activity of antimicrobial-impregnated devices. | 2006 Apr |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
| Allergic contact dermatitis to chloroxylenol. | 2006 Sep |
|
| Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approach. | 2007 Dec 10 |
|
| Determinants of disease presentation and outcome during cryptococcosis: the CryptoA/D study. | 2007 Feb |
|
| Chloroxylenol. | 2007 Jun |
|
| A review of anti-septic agents for pre-operative skin preparation. | 2007 Oct-Dec |
|
| Evaluation of estrogenic activity of organic biocides using ER-binding and YES assay. | 2007 Sep |
|
| Susceptibility pattern of some clinical bacterial isolates to selected antibiotics and disinfectants. | 2008 |
|
| Mineralization of the biocide chloroxylenol by electrochemical advanced oxidation processes. | 2008 Apr |
|
| In-vitro activity and in-vivo efficacy of catheters impregnated with chloroxylenol and thymol against uropathogens. | 2008 Feb |
|
| Simultaneous determination of 21 preservatives in cosmetics by ultra performance liquid chromatography. | 2008 Oct |
|
| Occupation-related contact dermatitis in North American health care workers referred for patch testing: cross-sectional data, 1998 to 2004. | 2008 Sep-Oct |
|
| Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening. | 2009 |
|
| Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles. | 2009 Dec 2 |
|
| Hand dermatitis: a focus on allergic contact dermatitis to biocides. | 2009 Jul |
|
| Degradation of the biocide 4-chloro-3,5-dimethylphenol in aqueous medium with ozone in combination with ultraviolet irradiation: operating conditions influence and mechanism. | 2009 Nov |
|
| Newborn care practices among slum dwellers in Dhaka, Bangladesh: a quantitative and qualitative exploratory study. | 2009 Nov 17 |
|
| The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus. | 2009 Oct |
|
| Vaginal practices of HIV-negative Zimbabwean women. | 2010 |
|
| Determination of phenolic disinfectants in consumer products by capillary electrophoresis with amperometric detection. | 2010 Aug |
|
| Screening level ecological risk assessment for phenols in surface water of the Taihu Lake. | 2010 Aug |
|
| Drug structure-transport relationships. | 2010 Dec |
|
| A case of intermittent explosive disorder. | 2010 Jan |
|
| Vaginal practices and associations with barrier methods and gel use among Sub-Saharan African women enrolled in an HIV prevention trial. | 2010 Jun |
|
| Preliminary phytochemical screening and in vitro antioxidant activities of the aqueous extract of Helichrysum longifolium DC. | 2010 May 14 |
|
| Evaluation of the tissue toxicity of antiseptics by the hen's egg test on the chorioallantoic membrane (HETCAM). | 2010 May 18 |
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259-424-1
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DTXSID5068990
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54983-54-9
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Z45I1DM6NJ
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23668630
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SUBSTANCE RECORD
