Details
Stereochemistry | ACHIRAL |
Molecular Formula | Si |
Molecular Weight | 28.0855 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Si]
InChI
InChIKey=BLRPTPMANUNPDV-UHFFFAOYSA-N
InChI=1S/H4Si/h1H4
DescriptionSources: http://www.hmdb.ca/metabolites/HMDB02175Curator's Comment: description was created based on several sources, including
https://livertox.nlm.nih.gov//TraceElementsAndMetals.htm | https://www.ncbi.nlm.nih.gov/pubmed/17435952 | https://www.ncbi.nlm.nih.gov/pubmed/17968615
Sources: http://www.hmdb.ca/metabolites/HMDB02175
Curator's Comment: description was created based on several sources, including
https://livertox.nlm.nih.gov//TraceElementsAndMetals.htm | https://www.ncbi.nlm.nih.gov/pubmed/17435952 | https://www.ncbi.nlm.nih.gov/pubmed/17968615
Silicon is a trace element that resembles carbon and can form silicon-carbon as well as silicon-oxygen, silicon-hydrogen and silicon-nitrogen bonds. It may have a role in a number of areas of human physiology and metabolism, especially bone and connective tissue formation, but possibly also gene expression and cardiovascular health. The exact biological role(s) of silicon in bone health is still not clear, although a number of possible mechanisms have been suggested, including the synthesis of collagen and/or its stabilization, and matrix mineralization. Silicone-based products are widely used in the management of hypertrophic scarring and keloids. The mechanism of action of silicone therapy has not been completely determined but is likely to involve occlusion and hydration of the stratum corneum with subsequent cytokine-mediated signaling from keratinocytes to dermal fibroblasts.
CNS Activity
Originator
Approval Year
Sample Use Guides
Silicone Sheets: 1 application a day for 12 to 23 hours for at least 2 months.
Silicone Gel: Apply very thinly in the morning and evening (1x a day under occlusive bandage) for at least 2 months.
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1334616
Silicon-containing compound zeolite A (ZA) increases eggshell thickness in hens. Treatment of nearly homogeneous strains of normal human osteoblast-like cells for 48 h with ZA at 0.1-100 micrograms/ml induced a dose-dependent increase (r = 0.35, P < 0.001) in DNA synthesis (n = 31) to 162 +/- 16% (mean +/- SEM) of control and in the proportion of cells in mitosis (n = 4) from 9.1 +/- 1.8 to 27.0 +/- 4.5% (r = 0.69, P < 0.005). ZA treatment also increased alkaline phosphatase activity (P < 0.05) and osteocalcin release (P < 0.05) but did not significantly affect collagen production per individual cell.
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DSLD |
146 (Number of products:1149)
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NCI_THESAURUS |
C1940
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9774
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Z4152N8IUI
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7440-21-3
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DTXSID0051441
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100000151810
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Z4152N8IUI
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27573
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DB12982
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SUB126233
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231-130-8
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5461123
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C84589
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D012825
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m9900
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ACTIVE MOIETY