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Details

Stereochemistry ACHIRAL
Molecular Formula C11H11N4O3S.Na
Molecular Weight 302.285
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULFAMONOMETHOXINE SODIUM

SMILES

[Na+].COC1=NC=NC([N-]S(=O)(=O)C2=CC=C(N)C=C2)=C1

InChI

InChIKey=IZJAOWYNDLDRKM-UHFFFAOYSA-N
InChI=1S/C11H11N4O3S.Na/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9;/h2-7H,12H2,1H3;/q-1;+1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.goldbio.com/product/3383/sulfamonomethoxine http://ft.chqmarket.com/en/1059-compound-sulfamonomethoxine-sodium-injection-baclean.html

Sulfamonomethoxine is a long-acting sulfonamide antibiotic. It is active against Streptococcus spp. (Including Streptococcus pneumoniae, Enterococcus spp.), Staphylococcus spp., Escherichia coli, Shigella spp., some strains of Proteus spp., Neisseria gonorrhoeae, Neisseria meningitides. Sulfamonomethoxine also active against Chlamydia spp., Toxoplasma gondii, Plasmodium. Rapidly absorbed from the gastrointestinal tract, it penetrates the BBB. The relatively low toxicity. Sulfamonomethoxine is a competitive inhibitor of dihydropteroate synthetase used to block the synthesis of folic acid. By preventing the production of folate in bacteria, the sulfonamide antibiotics ultimately suppress bacterial DNA replication.

CNS Activity

Curator's Comment: BACLEAN (Sulfamonomethoxine Sodium and Trimethoprim ) can rapidly penetrate the blood-brain barrier and maintain high blood concentration http://ft.chqmarket.com/en/1059-compound-sulfamonomethoxine-sodium-injection-baclean.html

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.
1995 Aug
In-vitro antifungal activities of sulfa drugs against clinical isolates of Aspergillus and Cryptococcus species.
2007
Patents

Patents

Sample Use Guides

adult: 1 tablet per day (500 mg- 1 g per day) children: 25 mg/kg per day at the first day, then 12,5 mg/kg per day
Route of Administration: Oral
In Vitro Use Guide
It was shown that 9 strains of P. mallei were sensitive to sulfanilamides and their combinations with trimethoprim: sulfamonomethoxine + trimethoprim (2.5:1), etc. The activity of the sulfamonomethoxine combination with trimethoprim (sulfate) was lower.
Name Type Language
SULFAMONOMETHOXINE SODIUM
Common Name English
BENZENESULFONAMIDE, 4-AMINO-N-(6-METHOXY-4-PYRIMIDINYL)-, SODIUM SALT (1:1)
Common Name English
SODIUM SULFAMONOMETHOXINE
Common Name English
SULFAMONOMETHOXINE SODIUM SALT
Common Name English
BENZENESULFONAMIDE, 4-AMINO-N-(6-METHOXY-4-PYRIMIDINYL)-, MONOSODIUM SALT
Common Name English
Code System Code Type Description
CAS
38006-08-5
Created by admin on Sat Dec 16 06:57:25 GMT 2023 , Edited by admin on Sat Dec 16 06:57:25 GMT 2023
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SMS_ID
300000029183
Created by admin on Sat Dec 16 06:57:25 GMT 2023 , Edited by admin on Sat Dec 16 06:57:25 GMT 2023
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EPA CompTox
DTXSID701033986
Created by admin on Sat Dec 16 06:57:25 GMT 2023 , Edited by admin on Sat Dec 16 06:57:25 GMT 2023
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PUBCHEM
656643
Created by admin on Sat Dec 16 06:57:25 GMT 2023 , Edited by admin on Sat Dec 16 06:57:25 GMT 2023
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FDA UNII
YY7L7A5XHO
Created by admin on Sat Dec 16 06:57:25 GMT 2023 , Edited by admin on Sat Dec 16 06:57:25 GMT 2023
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