U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C23H25ClN2O9
Molecular Weight 508.906
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOMOCYCLINE

SMILES

[H][C@@]12C[C@@]3([H])C(C(=O)C4=C(O)C=CC(Cl)=C4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(=O)NCO)=C(O)[C@H]2N(C)C

InChI

InChIKey=GJGDLRSSCNAKGL-KMVLDZISSA-N
InChI=1S/C23H25ClN2O9/c1-22(34)8-6-9-16(26(2)3)18(30)14(21(33)25-7-27)20(32)23(9,35)19(31)12(8)17(29)13-11(28)5-4-10(24)15(13)22/h4-5,8-9,16,27-28,30-31,34-35H,6-7H2,1-3H3,(H,25,33)/t8-,9-,16-,22-,23-/m0/s1

HIDE SMILES / InChI
Clomocycline is the approved name of a methylol derivative of chlortetracycline. Clomocycline is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Clomocycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease. Clomocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Clomocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. This drug has been reported to be noticeably free of side-effects such as nausea, vomiting, and diarrhea.

Approval Year

Sample Use Guides

17 mg/kg (1 capsule per 10 kg.) in a single dose or two doses taken at an interval of 6-8 hours; 34 mg/kg divided into two or three doses taken at 6-hourly intervals
Route of Administration: Oral
Name Type Language
CLOMOCYCLINE
INN   MI   WHO-DD  
INN  
Official Name English
7-CHLORO-4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,6,10,12,12A-PENTAHYDROXY-N-(HYDROXYMETHYL)-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE
Common Name English
Clomocycline [WHO-DD]
Common Name English
clomocycline [INN]
Common Name English
CLOMOCYCLINE [MI]
Common Name English
Classification Tree Code System Code
WHO-ATC J01AA11
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
NCI_THESAURUS C1595
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
WHO-VATC QJ01AA11
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID80905089
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
PRIMARY
SMS_ID
100000084527
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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CHEBI
59589
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
PRIMARY
WIKIPEDIA
CLOMOCYCLINE
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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MESH
C007090
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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INN
2151
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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CAS
1181-54-0
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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ChEMBL
CHEMBL2106071
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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FDA UNII
YP0241BU76
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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EVMPD
SUB06726MIG
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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MERCK INDEX
m1081
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
PRIMARY Merck Index
DRUG BANK
DB00453
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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DRUG CENTRAL
702
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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RXCUI
21272
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
PRIMARY RxNorm
NCI_THESAURUS
C76236
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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