BENZOBARBITAL

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H16N2O4
Molecular Weight	336.3413
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1(C(=O)NC(=O)N(C(=O)C2=CC=CC=C2)C1=O)C3=CC=CC=C3

InChI

InChIKey=QMOWPJIFTHVQMB-UHFFFAOYSA-N

InChI=1S/C19H16N2O4/c1-2-19(14-11-7-4-8-12-14)16(23)20-18(25)21(17(19)24)15(22)13-9-5-3-6-10-13/h3-12H,2H2,1H3,(H,20,23,25)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3188749 | https://www.rlsnet.ru/tn_index_id_4242.htm | https://www.ncbi.nlm.nih.gov/pubmed/13967208

Benzobarbital (under the brand name Benzona), a barbiturate derivative developed in Russia that is used to treat convulsive forms of epilepsy, newborn hemolytic disease, and insomnia.

Approval Year

PubMed

Title	Date	PubMed
[Prospects of using hard dispersions in development of dosage forms for therapeutic and prophylactic use].	2001	11255953
[The liver monooxygenase system activity in the long-term compression syndrome and treatment with benzonal in prepubertal rats and rabbits].	2001 Mar-Apr	11548454
[Effect of benzonal on the absorptive-secretory function in the liver of immature rabbits in post-compression period of long-term compression syndrome].	2001 May-Jun	11558444
[A comparative study of efferent methods of treatment and bezonal on the absorptive and excretory liver function in patients with acute diffuse peritonitis].	2002	12073258
[Effect of benzonal and hyperbaric oxygenation on the intensity of the lipid peroxidation process and activity of the antioxidant system in patient with acute diffuse peritonitis].	2002 Apr-Jun	12145897
[Liver monooxygenase system inducers in the treatment of respiratory distress syndrome in newborn].	2002 Mar	11980138
Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis.	2002 Sep	12512000
[Efficacy of enzyme-inducing agents in experimental tetrachloromethane poisoning].	2003 Jul-Aug	14558353
[Influence of psychotropic drugs on thrombocytes aggregation in patients with epilepsy].	2004	15581040
[The effect of Asian cobra venom on the content of rat heart and liver mitochondrial phospholipids and the protective effect of benzonal].	2005 Sep-Oct	16342667
[Analysis of blood hormone levels in boys of prepubertal and pubertal age with epilepsy treated with different antiepileptic drugs].	2008	19618713

Sample Use Guides

In Vivo Use Guide

For adults: 0.1 g 3 times a day (the highest daily dose is 0.8 g), for children (3 times a day): 3–6 years - 0.025–0.05 g, 7–10 years - 0, 05–0.1 g, 11–14 years old - 0.1 g (the highest daily is 0.45 g);

Route of Administration: Oral

Name

Type

Language

BENZOBARBITAL

Official Name

English

Benzobarbital [WHO-DD]

Common Name

English

BENZOBARBITAL [MART.]

Common Name

English

benzobarbital [INN]

Common Name

English

1-BENZOYL-5-ETHYL-5-PHENYLBARBITURIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67084