Details
Stereochemistry | ACHIRAL |
Molecular Formula | C7H4O5.Bi.HO |
Molecular Weight | 394.0914 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[OH-].[Bi+3].OC(=O)C1=CC(O)=C([O-])C([O-])=C1
InChI
InChIKey=JAONZGLTYYUPCT-UHFFFAOYSA-K
InChI=1S/C7H6O5.Bi.H2O/c8-4-1-3(7(11)12)2-5(9)6(4)10;;/h1-2,8-10H,(H,11,12);;1H2/q;+3;/p-3
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/22527308Curator's Comment: description was created based on several sources, including
https://www.drugs.com/international/bibrocathol.html | https://clinicaltrials.gov/ct2/show/NCT01357538 | https://www.drugs.com/international/noviform.html | https://www.ncbi.nlm.nih.gov/pubmed/17003947
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22527308
Curator's Comment: description was created based on several sources, including
https://www.drugs.com/international/bibrocathol.html | https://clinicaltrials.gov/ct2/show/NCT01357538 | https://www.drugs.com/international/noviform.html | https://www.ncbi.nlm.nih.gov/pubmed/17003947
Bibrocathol (trade names Noviform and Posiformin) is a well-established topical antiseptic for the treatment of acute eyelid diseases like blepharitis. Eye ointments containing 2 or 5 % bibrocathol and the excipients liquid paraffin, white soft paraffin, and lanolin have been marketed since 1967 for the treatment of eye irritation, chronic blepharitis, and uninfected corneal injuries. Reports of clinical experience with bibrocathol for inflammation of the edge of the palpebra exist since the beginning of the 20th century. Until recently, no controlled, randomized clinical studies according to the guidelines for Good Clinical Practice for Trials on Medical Products for Human Use (GCP) as defined by the International Conference on Harmonisation (ICH) have been performed with bibrocathol 2 % ointment, as these were not required for marketing authorization in the 1960s. A first double-blind, prospective, controlled, GCP-compliant clinical study was recently performed to assess the efficacy of bibrocathol 5 % (Noviform®) in acute blepharitis. It demonstrated superior efficacy of bibrocathol 5 % ointment as compared to an ointment vehicle (placebo) after 2 weeks of treatment as assessed by a combined measure of slit-lamp examination results and patients’ subjective complaints.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL614976 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28837052 |
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Target ID: CHEMBL612314 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28837052 |
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Target ID: CHEMBL612614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28837052 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | Noviform Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22527308
A strip of 5 mm eye ointment applied 3 times per day to the eye lid
Route of Administration:
Topical
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C28394
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CFR |
21 CFR 331.11
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CFR |
21 CFR 357.850
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CFR |
21 CFR 331.15
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EPA PESTICIDE CODE |
98601
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CFR |
21 CFR 357.810
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19476
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YIW503MI7V
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31292
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DB13909
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99-26-3
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C77029
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202-742-2
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73415769
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BISMUTH SUBGALLATE
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C002170
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m2553
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PRIMARY | Merck Index |
ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD