| Stereochemistry | EPIMERIC |
| Molecular Formula | C20H24O10 |
| Molecular Weight | 424.3986 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@@H](OC2=CC=CC=C2COC(=O)C3(O)C=CCCC3=O)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=CZDNLUMNELLDDD-QZFWYPLZSA-N
InChI=1S/C20H24O10/c21-9-13-15(23)16(24)17(25)18(30-13)29-12-6-2-1-5-11(12)10-28-19(26)20(27)8-4-3-7-14(20)22/h1-2,4-6,8,13,15-18,21,23-25,27H,3,7,9-10H2/t13-,15-,16+,17-,18-,20?/m1/s1
Salicortin, a phenolic glycoside, is the dominant secondary metabolites in many plants, including Populus and Salix species, and exerts various biological effects, such as anti-amnesic and anti-adipogenic effects. It was reported that salicortin significantly inhibited iNOS expression and NO production in LPS-stimulated macrophages and microglia. Salicortin suppressed TNF-α-induced ICAM-1 expression in human endothelial cells. These studies suggest that salicortin has immune-modulatory activity, even though the molecular action mechanism for this activity has not been fully determined. Recently also was dfiscovered that salicortin may be of interest in developments of treatment for osteoclast related diseases by down-regulating JNK and NF-κB/NFATc1 signaling pathways.
Approval Year
PubMed
Sample Use Guides
Effects of salicortin on LPS-induced iNOS expression and NO production in RAW 264.7 macrophages was studied. Cells were pretreated with the indicated concentrations of salicortin (10-40 ug/mL) for 3 h and were then stimulated with LPS (1 μg/ml) for 18 h (for protein) or 4 h (for mRNA). Cell lysates were electrophoresed and the protein expression of iNOS was detected by the specific antibody. Salicortin-mediated inhibition of NO production in LPS-stimulated RAW 264.7 cells is associated with the inhibition of iNOS expression at a transcriptional level.
SUBSTANCE RECORD
