U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C11H14ClN
Molecular Weight 195.689
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENALFOCIN

SMILES

CN1CCC2=C(CC1)C(Cl)=CC=C2

InChI

InChIKey=RSRUDTPYRBLHEO-UHFFFAOYSA-N
InChI=1S/C11H14ClN/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13/h2-4H,5-8H2,1H3

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
82.0 nM [Ki]
PubMed

PubMed

TitleDatePubMed
alpha-1 and alpha-2 Adrenergic antagonists relieve thermal hyperalgesia in experimental mononeuropathy from chronic constriction injury.
2001 Jun
Ventilatory effects of alpha2-adrenoceptor blockade in awake goats.
2001 May
Non-adrenergic exploratory behavior induced by moxonidine at mildly hypotensive doses.
2003 Feb 21
Neuronal norepinephrine responses of the rostral ventrolateral medulla and nucleus tractus solitarius neurons distinguish the I1- from the alpha2-receptor-mediated hypotension in conscious SHRs.
2005 Jul
Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension.
2005 May 9
Clonidine-evoked respiratory effects in anaesthetized rats.
2006 Jan
Medial prefrontal cortical alpha1 adrenoreceptor modulation of the nucleus accumbens dopamine response to stress in Long-Evans rats.
2007 Apr
Cathine, an amphetamine-related compound, acts on mammalian spermatozoa via beta1- and alpha2A-adrenergic receptors in a capacitation state-dependent manner.
2007 Mar
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
2008 Jul 28
Name Type Language
BENALFOCIN
Common Name English
LOPAC-S-1563
Code English
6-CHLORO-3-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE
Systematic Name English
SK&F-86466
Code English
Code System Code Type Description
CAS
73943-10-9
Created by admin on Fri Dec 15 19:42:13 GMT 2023 , Edited by admin on Fri Dec 15 19:42:13 GMT 2023
PRIMARY
EPA CompTox
DTXSID70224650
Created by admin on Fri Dec 15 19:42:13 GMT 2023 , Edited by admin on Fri Dec 15 19:42:13 GMT 2023
PRIMARY
PUBCHEM
123981
Created by admin on Fri Dec 15 19:42:13 GMT 2023 , Edited by admin on Fri Dec 15 19:42:13 GMT 2023
PRIMARY
FDA UNII
YCN2U5UGIQ
Created by admin on Fri Dec 15 19:42:13 GMT 2023 , Edited by admin on Fri Dec 15 19:42:13 GMT 2023
PRIMARY