Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H20Br2N2.ClH |
Molecular Weight | 412.591 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN(CC1=C(N)C(Br)=CC(Br)=C1)C2CCCCC2
InChI
InChIKey=UCDKONUHZNTQPY-UHFFFAOYSA-N
InChI=1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H
DescriptionCurator's Comment: description was created based on several sources, including:
http://www.drugsupdate.com/generic/view/745/Bromhexine | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/5329.pdf | https://docetp.mpa.se/LMF/Bisolvon%20oral%20solution%20in%20sachet%20ENG%20PAR.pdf
Curator's Comment: description was created based on several sources, including:
http://www.drugsupdate.com/generic/view/745/Bromhexine | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/5329.pdf | https://docetp.mpa.se/LMF/Bisolvon%20oral%20solution%20in%20sachet%20ENG%20PAR.pdf
Bromhexine is used for conditions where there are a lot of thick mucus in the airways. Bromhexine acts on the mucus at the formative stages in the glands, within the mucus-secreting cells. Bromhexine disrupts the structure of acid mucopolysaccharide fibres in mucoid sputum and produces a less viscous mucus, which is easier to expectorate. In addition, bromhexine has antioxidant properties. Occasional, mild side effects include: a feeling of fullness in the stomach (bloatedness), diarrhea, dizziness, headache, indigestion, nausea, sweating and skin rashes. Bromhexine may increase the concentration of concurrently administered antibiotics in bronchial secretions. No clinically relevant interactions with other medications have been reported.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:1903510 |
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Target ID: GO:0006979 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8831801 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Palliative | Bisolvon Approved UseSecretolytic therapy in acute and chronic bronchopulmonary diseases associated with abnormal
mucus secretion and impaired mucus transport. |
PubMed
Title | Date | PubMed |
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Role of mucolytics in the management of COPD. | 2006 |
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[Imaging of metabolic bone diseases]. | 2006 |
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Congenital aorto-azygous fistula treated with coil embolization: case report and review of the literature. | 2006 Sep-Oct |
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[Abdominal tuberculosis in CT imaging]. | 2007 |
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Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs. | 2007 Feb 19 |
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Amiodarone inhibits tocopherol-mediated human lipoprotein peroxidation. | 2007 Jul 15 |
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Design and evaluation of deformable talc agglomerates prepared by crystallo-co-agglomeration technique for generating heterogeneous matrix. | 2007 Jul 27 |
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Growth rate of locally recurrent hepatocellular carcinoma after transcatheter arterial chemoembolization: comparing the growth rate of locally recurrent tumor with that of primary hepatocellular carcinoma. | 2007 Mar |
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Acute cholecystitis due to strangulation of a floating gallbladder by the lesser omentum. | 2007 May-Jun |
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Pulmonary Paragonimus westermani with false-positive fluorodeoxyglucose positron emission tomography mimicking primary lung cancer. | 2007 Nov |
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Voltammetric behaviour of bromhexine and its determination in pharmaceuticals. | 2007 Oct 31 |
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Protective effect of Adhatoda vascia Nees against radiation-induced damage at cellular, biochemical and chromosomal levels in Swiss albino mice. | 2007 Sep |
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The role for S-carboxymethylcysteine (carbocisteine) in the management of chronic obstructive pulmonary disease. | 2008 |
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Successful resection of dermatomyositis associated with thymic carcinoma: report of a case. | 2008 |
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Oromandibular dystonia and persistent psychiatric symptoms in extra-pontine myelinolysis. | 2008 Apr |
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Unsuspected breast carcinoma presenting as orbital complication of rhinosinusitis. | 2008 Aug |
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Challenges of utilizing immunostains to facilitate the diagnosis and management of metastatic adenocarcinoma. | 2008 Dec |
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Bioequivalence study of bromhexine by liquid chromatography-electrospray ionization-mass spectrometry after oral administration of bromhexine hydrochloride tablets. | 2008 Dec 1 |
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Subjective pulsatile tinnitus associated with extensive pneumatization of temporal bone. | 2008 Jan |
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Chemiluminescence determination of bromhexine hydrochloride with morin as chemiluminescent reagent. | 2008 Jan-Feb |
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Development and evaluation of oral controlled release chlorpheniramine-ion exchange resinate suspension. | 2008 Jul-Aug |
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Three case reports of laparoscopic management of granulosa cell tumor with intraoperative rupture and subsequent upstaging. | 2008 Jul-Aug |
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Recent developments in the treatment of alcoholic chronic pancreatitis. | 2008 Jun |
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Malignant medulloepithelioma of optic nerve head. | 2008 Jun |
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Perinatal tumours: the contribution of radiology to management. | 2008 Jun |
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Simultaneous UV Spectrophotometric Estimation of Ambroxol Hydrochloride and Levocetirizine Dihydrochloride. | 2008 Mar-Apr |
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Mediastinal pancreatic pseudocyst with isolated thoracic symptoms: a case report. | 2008 May 27 |
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Huge ascending aortic pseudoaneurysm caused by a penetrating atherosclerotic ulcer. | 2008 Nov |
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A simple micellar electrokinetic capillary chromatographic method for the quantitative analysis of organic expectorants. | 2008 Sep |
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The effect of retroperitoneal fat tissue thickness on testicular venous drainage. | 2009 |
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Pancreatic cancer metastasis to the rectum detected on colonoscopy. | 2009 |
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Evaluation of a combined strategy directed towards health-care professionals and patients with chronic obstructive pulmonary disease (COPD): information and health education feedback for improving clinical monitoring and quality-of-life. | 2009 Dec 1 |
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Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles. | 2009 Dec 2 |
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Simultaneous determination of salbutamol sulphate and bromhexine hydrochloride in tablets by reverse phase liquid chromatography. | 2009 Jan |
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Feline herpesvirus infection. ABCD guidelines on prevention and management. | 2009 Jul |
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Acidic and basic solutions dissolve protein plugs made of lithostathine complicating choledochal cyst/pancreaticobiliary maljunction. | 2009 Jul |
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Activity of some mucolytics against bacterial adherence to mammalian cells. | 2009 Jul |
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[Acute mediastinitis--optimum diagnostic and therapeutic measures]. | 2009 May |
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[Pharmacological treatment of acute cough]. | 2009 May 14 |
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Differential modulation of IgE-dependent activation of human basophils by ambroxol and related secretolytic analogues. | 2009 Oct-Dec |
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Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms. | 2010 |
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Ambroxol - Resurgence of an old molecule as an anti-inflammatory agent in chronic obstructive airway diseases. | 2010 Apr |
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Quantification of the major metabolites of bromhexine in human plasma using RRLC-MS/MS and its application to pharmacokinetics. | 2010 Apr 6 |
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Anatomical suitability for endovascular AAA repair may affect outcomes following rupture. | 2010 Aug |
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Tuberculosis should not be ignored in patients with peripheral gangrene. | 2010 Dec |
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Effect of drug content and agglomerate size on tabletability and drug release characteristics of bromhexine hydrochloridetalc agglomerates prepared by crystallo-co-agglomeration. | 2010 Mar |
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[Codeine and cutaneous drug reactions: Absence of cross-allergy with tramadol and fentanyl]. | 2010 May |
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[Juvenile Gougerot Sjögren syndrome: report of 3 cases]. | 2010 Nov |
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Superior mesenteric artery aneurysm: importance of sonography as the primary imaging technique for detection. | 2010 Oct |
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Contaminations of herbal products determined by NMR fingerprint. | 2010 Sep |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8831801
Bromhexine is shown to be scavengers of both superoxide and hydroxyl radicals. The dismutation of superoxide was accelerated 3-fold by bromhexine over the rate of spontaneous dismutation. The reaction constant of hydroxyl radicals with bromhexine was determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1.
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NCI_THESAURUS |
C74536
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PRIMARY | Merck Index |
ACTIVE MOIETY
SUBSTANCE RECORD