U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Monolaurin, derived naturally from coconut, is a source of the medium chain fatty acid lauric acid. Monolaurin has been widely researched for its antiviral, antibacterial, and antimicrobial properties, as it can break down and destroy the lipid layer of enveloped viruses where many pharmaceuticals fail. Fatty acids and monoglycerides produce their killing/inactivating effects by several mechanisms. An early postulated mechanism was the perturbing of the plasma membrane lipid bilayer. The antiviral action attributed to monolaurin is that of fluidizing the structure in the envelope of the virus, causing the disintegration of the microbial membrane. More recent studies, indicate that one antimicrobial effect in bacteria is related to monolaurin's interference with signal transduction/toxin formation. Another antimicrobial effect in viruses is due to lauric acid's interference with virus assembly and viral maturation. The third mode of action may be on the immune system itself. Monolaurin does not appear to have an adverse effect on desirable gut bacteria, but rather on only potentially pathogenic microorganisms. It is classified by the FDA as "generally regarded as safe" (GRAS).

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P06886
Gene ID: NA
Gene Symbol: tst
Target Organism: Staphylococcus aureus
Target ID: P01583
Gene ID: 3552
Gene Symbol: IL1A
Target Organism: Homo sapiens (Human)
Conditions
PubMed

PubMed

TitleDatePubMed
Glycerol monolaurate prevents mucosal SIV transmission.
2009 Apr 23
Patents

Patents

Sample Use Guides

In Vivo Use Guide
The recommended initial level is ~0.75 gram or less two or three times daily for a week before increasing the amount. The level can be then increased to 1.5 grams one, two or three times daily thereafter. A maintenance level can be 3.0 grams two or three times a day necessary for optimum health effects. Take with or after meals.
Route of Administration: Oral
In Vitro Use Guide
MIC dose range of 1-Monolaurin for 10 susceptible organisms from groups A and D is 0,045 uM/ml - NI (not inhibitory at concentrations tested). Max concentration tested was 3,63 uM/ml.
Name Type Language
GLYCERYL LAURATE
II   INCI  
INCI  
Official Name English
LAURIC ACID, MONOESTER WITH GLYCEROL
Common Name English
MONOMULS L 90
Brand Name English
MONOMULS 90-45
Brand Name English
LAURIC ACID MONOGLYCERIDE
Common Name English
GLYCERINE MONOLAURATE
WHO-DD  
Common Name English
MONOLAUROYL GLYCEROL
Common Name English
GLYCERYL LAURATE [II]
Common Name English
DIMODAN ML 90
Brand Name English
MONODODECANOYL GLYCEROL
Common Name English
MONOMULS 90L12
Brand Name English
ELECTROSTRIPPER TS 14B
Brand Name English
GLYCERYL MONODODECANOATE
Common Name English
GLYCERINE MONOLAURATE [WHO-DD]
Common Name English
DODECANOIC ACID, MONOESTER WITH 1,2,3-PROPANETRIOL
Common Name English
NSC-4837
Code English
ALDO MLD
Brand Name English
LAURIC MONOGLYCERIDE
Common Name English
SUNSOFT 750
Brand Name English
DENON 2659
Brand Name English
POEM M 300
Brand Name English
GLYCERYL LAURATE [INCI]
Common Name English
GLYCEROL MONOLAURATE
Common Name English
MONOGLYCEROL LAURATE
Common Name English
GLYCEROX L 8
Brand Name English
GLYCERYL MONOLAURATE [VANDF]
Common Name English
IMWITOR 312
Brand Name English
SUNSOFT 757
Brand Name English
LAURIN, MONO-
Common Name English
MONOLAUROYLGLYCERIN
Common Name English
GLYCERYL MONOLAURATE
VANDF  
Common Name English
TEGIN L 90
Brand Name English
LAURACIDIN
Common Name English
MONOLAURIN [VANDF]
Common Name English
MONOLAURIN
VANDF  
Common Name English
RYLO-MG 12
Brand Name English
CITHROL GML
Brand Name English
GRINDTEK ML 90
Brand Name English
RIKEMAL M 300
Brand Name English
GLYCEROL MONODODECANOATE
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 71892
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
DSLD 4137 (Number of products:3)
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
NCI_THESAURUS C83486
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
EPA PESTICIDE CODE 11290
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
DSLD 3576 (Number of products:17)
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
Code System Code Type Description
EVMPD
SUB22053
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
PRIMARY
WIKIPEDIA
MONOLAURIN
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
PRIMARY
EPA CompTox
27215-38-9
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
PRIMARY
ECHA (EC/EINECS)
248-337-4
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
PRIMARY
FDA UNII
Y98611C087
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
PRIMARY
CAS
27215-38-9
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
PRIMARY
RXCUI
1311693
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
PRIMARY
RXCUI
314647
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
ALTERNATIVE
NCI_THESAURUS
C75644
Created by admin on Sat Jun 26 18:33:25 UTC 2021 , Edited by admin on Sat Jun 26 18:33:25 UTC 2021
PRIMARY
All of the following components must be present:
Definition References