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Details

Stereochemistry ACHIRAL
Molecular Formula C16H13FN4O2
Molecular Weight 312.2984
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of R-112

SMILES

OC1=CC(NC2=NC=C(F)C(NC3=CC=CC(O)=C3)=N2)=CC=C1

InChI

InChIKey=TVKGTSHBQZEFEE-UHFFFAOYSA-N
InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21)

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
226.0 nM [IC50]
Target ID: Leukotriene C4 production
Name Type Language
R-112
Code English
PHENOL, 3,3'-((5-FLUORO-2,4-PYRIMIDINEDIYL)DIIMINO)BIS-
Systematic Name English
3-((5-FLUORO-2-(3-HYDROXYANILINO)PYRIMIDIN-4-YL)AMINO)PHENOL
Systematic Name English
R-921218
Code English
R112
Code English
3,3'-((5-FLUORO-2,4-PYRIMIDINEDIYL)DIIMINO)BIS(PHENOL)
Systematic Name English
Code System Code Type Description
FDA UNII
Y7W5AL9KHB
Created by admin on Sat Dec 16 11:14:23 GMT 2023 , Edited by admin on Sat Dec 16 11:14:23 GMT 2023
PRIMARY
PUBCHEM
9904854
Created by admin on Sat Dec 16 11:14:23 GMT 2023 , Edited by admin on Sat Dec 16 11:14:23 GMT 2023
PRIMARY
CLINICAL_TRIALS.GOV
R-921218
Created by admin on Sat Dec 16 11:14:23 GMT 2023 , Edited by admin on Sat Dec 16 11:14:23 GMT 2023
PRIMARY This is a study of the effectiveness and safety of a new nasal spray for the relief of the symptoms of seasonal allergies. The agents being compared are: R926112 (a novel anti-allergy medicine), Beconase (beclomethasone dipropionate, an established FDA approved steroid treatment), and an inactive placebo. The study hypothesis is that R926112 will be superior to placebo at the end of a week of testing and evaluation. The study does not have the power to determine how R926112 compares to Beconase.
ChEMBL
CHEMBL3545399
Created by admin on Sat Dec 16 11:14:23 GMT 2023 , Edited by admin on Sat Dec 16 11:14:23 GMT 2023
PRIMARY
CAS
575474-82-7
Created by admin on Sat Dec 16 11:14:23 GMT 2023 , Edited by admin on Sat Dec 16 11:14:23 GMT 2023
PRIMARY