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Details

Stereochemistry ACHIRAL
Molecular Formula C19H24N2
Molecular Weight 280.4073
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BAMIPINE

SMILES

CN1CCC(CC1)N(CC2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=VZSXTYKGYWISGQ-UHFFFAOYSA-N
InChI=1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3

HIDE SMILES / InChI

Description

Bamipine (trade name Soventol) is a sedating antihistamine with pronounced sedative effects. Bamipine is a pharmaceutical drug acting as an H1 antihistamine with anticholinergic properties. It is used as an antipruritic ointment. Bamipine hydrochloride has been given by mouth. Bamipine, bamipine lactate, and bamipine salicylate have all been applied topically.

CNS Activity

CNS Active
3913
Curator's Comment: Bamipine is an antihistamine with pronounced sedative effects.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Soventol

Approved Use

Allergic conditions
PubMed

PubMed

TitleDatePubMed
Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands.
2007 Dec 1
Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives.
2008 Dec 15
Patents

Patents

EP1641446A1
8
US20080227757
5
US20140065203
5

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Can be used topically: A thin layer applied on the surface of the skin. Re-application is possible in 30 min. Duration of treatment depends on allergic process. http://www.druginfosys.com/drug.aspx?drugcode=1567&type=1
The recommended dose is 50-100 mg 3-4 times/day.
Route of Administration: Oral
In Vitro Use Guide
Bamipine treatment resulted in 29% of inhibition of Mycobacterium tuberculosis H37Rv (after 4 days by microplate alamar blue assay) at 6.25 ug/mL.
Name Type Language
BAMIPINE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
bamipine [INN]
Common Name English
4-(N-BENZYLANILINO)-1-METHYLPIPERIDINE
Systematic Name English
Bamipine [WHO-DD]
Common Name English
BAMIPINE [MI]
Common Name English
BAMIPINE [MART.]
Common Name English
Classification Tree Code System Code
WHO-VATC QR06AX01
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
WHO-ATC D04AA15
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
WHO-VATC QD04AA15
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
NCI_THESAURUS C29578
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
WHO-ATC R06AX01
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
Code System Code Type Description
EVMPD
SUB06098MIG
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
PUBCHEM
72075
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
DRUG CENTRAL
288
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
EPA CompTox
DTXSID5057751
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
ChEMBL
CHEMBL520400
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
MERCK INDEX
m2219
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
225-587-2
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
SMS_ID
100000088409
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
NCI_THESAURUS
C76058
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
INN
1285
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
DRUG BANK
DB13489
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
FDA UNII
Y6BHZ28O92
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
RXCUI
18753
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY RxNorm
WIKIPEDIA
BAMIPINE
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
CAS
4945-47-5
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
MESH
C020867
Created by admin on Sat Dec 16 17:50:13 GMT 2023 , Edited by admin on Sat Dec 16 17:50:13 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of BAMIPINE
SALT/SOLVATE (PARENT)
Structure of BAMIPINE HYDROCHLORIDE
SALT/SOLVATE (PARENT)
Structure of BAMIPINE LACTATE
NIH
NCATS
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