U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C18H15F3N2O2
Molecular Weight 348.3191
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUMIZOLE

SMILES

COC1=CC=C(C=C1)C2=C(N=C(N2)C(F)(F)F)C3=CC=C(OC)C=C3

InChI

InChIKey=OPYFPDBMMYUPME-UHFFFAOYSA-N
InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23)

HIDE SMILES / InChI

Description

FLUMIZOLE, a substituted diarylimidazole, is a weak acidic, nonsteroidal, anti-inflammatory agent. It is a potent cyclooxygenase inhibitor. FLUMIZOLE is severalfold more potent than indomethacin and 470 times more active than phenylbutazone in a system examining prostaglandin production.

CNS Activity

Originator

Approval Year

PubMed