Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C18H23N5O5.ClH |
| Molecular Weight | 425.867 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN1C2=C(N(CCCNCC(O)C3=CC(O)=CC(O)=C3)C=N2)C(=O)N(C)C1=O
InChI
InChIKey=XSFWDHONRBZVEJ-UHFFFAOYSA-N
InChI=1S/C18H23N5O5.ClH/c1-21-16-15(17(27)22(2)18(21)28)23(10-20-16)5-3-4-19-9-14(26)11-6-12(24)8-13(25)7-11;/h6-8,10,14,19,24-26H,3-5,9H2,1-2H3;1H
Reproterol is a short-acting β2 adrenoreceptor agonist used in the treatment of asthma. Reproterol increases the generation of cAMP in isolated peripheral blood monocytes in vitro more effectively than does orciprenaline. In the presence of the highly potent but nonselective ß-antagonist, propranolol, the cAMP-generating action of reproterol was inhibited only partially. Reproterol has gained wide use when it was licensed as a fixed combination therapy with cromoglycate. Until today, the bronchodilator effects of reproterol and the bronchoprotective and anti-inflammatory actions of cromoglycate combined in one inhaler remain the successful fixed combination of a disease-modifying and symptomatic drug for the treatment of asthma.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. | 2010-04 |
|
| Exercise-induced asthma: critical analysis of the protective role of montelukast. | 2009-10-22 |
|
| Multiresidue analysis of beta-agonists in bovine and porcine urine, feed and hair using liquid chromatography electrospray ionisation tandem mass spectrometry. | 2008-05 |
|
| Prevention of exercise-induced asthma by a fixed combination of disodium cromoglycate plus reproterol compared with montelukast in young patients. | 2008 |
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| Mononuclear cell membranes: stabilization by reproterol and cromoglycate, destabilization by fenoterol and salbutamol. | 2006 |
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| Effect of reproterol either alone or combined with disodium cromoglycate on airway responsiveness to methacholine. | 2005 |
|
| Different mechanisms of action of beta2-adrenergic receptor agonists: a comparison of reproterol, fenoterol and salbutamol on monocyte cyclic-AMP and leukotriene B4 production in vitro. | 2004-07-30 |
|
| Inhibition by reproterol of cAMP PDE in intact mastocytoma P-815 cells. | 2004 |
|
| [With the correct training conditions and appropriate prophylaxis. To make asthma patients fit for sports]. | 2003-04-10 |
|
| Conductimetric determination of reproterol HCl and pipazethate HCl and salbutamol sulphate in their pharmaceutical formulations. | 2001-10 |
|
| [Exercise-induced asthma. The spray belongs in the "athletic shoe"]. | 2001-07-19 |
|
| Screening of beta-2 agonists and confirmation of fenoterol, orciprenaline, reproterol and terbutaline with gas chromatography-mass spectrometry as tetrahydroisoquinoline derivatives. | 2001-02-10 |
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NCI_THESAURUS |
C319
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NCI_THESAURUS |
C48149
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235833
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DTXSID60926797
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235-942-3
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SUB04218MIG
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100000085251
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Y4I1COJ8W8
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3032600
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13055-82-8
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62932-27-8
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C152195
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m9529
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CHEMBL1095607
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ACTIVE MOIETY
SUBSTANCE RECORD
