Details
Stereochemistry | RACEMIC |
Molecular Formula | C18H23N5O5.ClH |
Molecular Weight | 425.867 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN1C2=C(N(CCCNCC(O)C3=CC(O)=CC(O)=C3)C=N2)C(=O)N(C)C1=O
InChI
InChIKey=XSFWDHONRBZVEJ-UHFFFAOYSA-N
InChI=1S/C18H23N5O5.ClH/c1-21-16-15(17(27)22(2)18(21)28)23(10-20-16)5-3-4-19-9-14(26)11-6-12(24)8-13(25)7-11;/h6-8,10,14,19,24-26H,3-5,9H2,1-2H3;1H
Reproterol is a short-acting β2 adrenoreceptor agonist used in the treatment of asthma. Reproterol increases the generation of cAMP in isolated peripheral blood monocytes in vitro more effectively than does orciprenaline. In the presence of the highly potent but nonselective ß-antagonist, propranolol, the cAMP-generating action of reproterol was inhibited only partially. Reproterol has gained wide use when it was licensed as a fixed combination therapy with cromoglycate. Until today, the bronchodilator effects of reproterol and the bronchoprotective and anti-inflammatory actions of cromoglycate combined in one inhaler remain the successful fixed combination of a disease-modifying and symptomatic drug for the treatment of asthma.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Phosphodiesterase, mouse Sources: https://www.ncbi.nlm.nih.gov/pubmed/15219266 |
52.0 µM [IC50] |
PubMed
Title | Date | PubMed |
---|---|---|
[Exercise-induced asthma. The spray belongs in the "athletic shoe"]. | 2001 Jul 19 |
|
Conductimetric determination of reproterol HCl and pipazethate HCl and salbutamol sulphate in their pharmaceutical formulations. | 2001 Oct |
|
[With the correct training conditions and appropriate prophylaxis. To make asthma patients fit for sports]. | 2003 Apr 10 |
|
Inhibition by reproterol of cAMP PDE in intact mastocytoma P-815 cells. | 2004 |
|
Different mechanisms of action of beta2-adrenergic receptor agonists: a comparison of reproterol, fenoterol and salbutamol on monocyte cyclic-AMP and leukotriene B4 production in vitro. | 2004 Jul 30 |
|
Effect of reproterol either alone or combined with disodium cromoglycate on airway responsiveness to methacholine. | 2005 |
|
Mononuclear cell membranes: stabilization by reproterol and cromoglycate, destabilization by fenoterol and salbutamol. | 2006 |
|
Prevention of exercise-induced asthma by a fixed combination of disodium cromoglycate plus reproterol compared with montelukast in young patients. | 2008 |
|
Multiresidue analysis of beta-agonists in bovine and porcine urine, feed and hair using liquid chromatography electrospray ionisation tandem mass spectrometry. | 2008 May |
|
Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. | 2010 Apr |
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Brand Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C319
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
||
|
NCI_THESAURUS |
C48149
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
235833
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY | RxNorm | ||
|
DTXSID60926797
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY | |||
|
235-942-3
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY | |||
|
SUB04218MIG
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY | |||
|
100000085251
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY | |||
|
Y4I1COJ8W8
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY | |||
|
3032600
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY | |||
|
13055-82-8
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY | |||
|
62932-27-8
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
SUPERSEDED | |||
|
C152195
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY | |||
|
m9529
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY | Merck Index | ||
|
CHEMBL1095607
Created by
admin on Fri Dec 15 15:20:04 GMT 2023 , Edited by admin on Fri Dec 15 15:20:04 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD