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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H28O2
Molecular Weight 240.3816
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROXIMADIOL

SMILES

[H][C@@]12C[C@@H](CC[C@@]1(C)CCC[C@@]2(C)O)C(C)(C)O

InChI

InChIKey=LKKDASYGWYYFIK-QHSBEEBCSA-N
InChI=1S/C15H28O2/c1-13(2,16)11-6-9-14(3)7-5-8-15(4,17)12(14)10-11/h11-12,16-17H,5-10H2,1-4H3/t11-,12-,14-,15-/m1/s1

HIDE SMILES / InChI
Proximadiol was isolated from the rhizomes of Zingiber mekongense and leaves of Blumea balsamifera. Compound lacks ativiral and antibacterial activity. Proximadiol was found to inhibit platelet-activating factor receptor binding on platelets at micromolar concentrations.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
A new diarylheptanoid from the rhizomes of Zingiber mekongense.
2011 Jun
Inhibitory effect of compounds from Goniothalamus tapis Miq. and Goniothalamus uvaroides King on platelet-activating factor receptor binding.
2012 May
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
The reaction mixture consisted of 200 mL of washed rabbit platelet suspension, 25 mL of 3H-PAF (2.0 nM) with or without unlabelled PAF (2.0 mM) and 15 mL of sample or control solution. The final concentrations of sample in the reaction mixtures were 18.2, 9.1, 4.5, 1.8 and 0.9 mg/mL. The reaction mixture was incubated at room temperature for 1 h. The free and bound ligands were separated by filtration technique using Whatman GF/C glass fibre filters. The final concentration of DMSO (control) in the reaction mixture was fixed at 0.1% to avoid interference with the receptor binding studies. The reaction mixture with 0.1% DMSO in saline was used as a control and cedrol was used as a positive control. The radioactivity was measured by scintillation counting. The difference between total radioactivities of bound 3H-PAF in the absence and presence of excess unlabelled PAF is defined as specific binding of the radiolabelled ligand.
Name Type Language
PROXIMADIOL
Common Name English
(1R,4AR,7R,8AR)-7-(2-HYDROXY-2-PROPANYL)-1,4A-DIMETHYLDECAHYDRO-1-NAPHTHALENOL
Systematic Name English
CRYPTOMERIDIOL
Common Name English
2-NAPHTHALENEMETHANOL, DECAHYDRO-8-HYDROXY-.ALPHA.,.ALPHA.,4A,8-TETRAMETHYL-, (2R-(2.ALPHA.,4A.ALPHA.,8.BETA.,8A.BETA.))-
Systematic Name English
5.BETA.,7.BETA.H,10.ALPHA.-EUDESMANE-4,11-DIOL
Common Name English
2-NAPHTHALENEMETHANOL, 1,2.BETA.,3,4,4A,5,6,7,8,8A.BETA.-DECAHYDRO-8.BETA.-HYDROXY-.ALPHA.,.ALPHA.,4A.ALPHA.,8-TETRAMETHYL-
Systematic Name English
2-NAPHTHALENEMETHANOL, DECAHYDRO-8-HYDROXY-.ALPHA.,.ALPHA.,4A,8-TETRAMETHYL-, (2R,4AR,8R,8AR)-
Systematic Name English
J13.424D
Code English
(2R,8R,8A.BETA.)-DECAHYDRO-8-HYDROXY-.ALPHA.,.ALPHA.,4A.ALPHA.,8-TETRAMETHYL-2-NAPHTHALENEMETHANOL
Systematic Name English
SELINA-4,7-DIOL
Common Name English
SELINANE-4.ALPHA.,11-DIOL
Common Name English
Code System Code Type Description
PUBCHEM
165258
Created by admin on Sat Dec 16 09:13:38 GMT 2023 , Edited by admin on Sat Dec 16 09:13:38 GMT 2023
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EPA CompTox
DTXSID001317282
Created by admin on Sat Dec 16 09:13:38 GMT 2023 , Edited by admin on Sat Dec 16 09:13:38 GMT 2023
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CAS
4666-84-6
Created by admin on Sat Dec 16 09:13:38 GMT 2023 , Edited by admin on Sat Dec 16 09:13:38 GMT 2023
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FDA UNII
Y2KBV9FZ9M
Created by admin on Sat Dec 16 09:13:38 GMT 2023 , Edited by admin on Sat Dec 16 09:13:38 GMT 2023
PRIMARY
RXCUI
2562551
Created by admin on Sat Dec 16 09:13:38 GMT 2023 , Edited by admin on Sat Dec 16 09:13:38 GMT 2023
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EVMPD
SUB69958
Created by admin on Sat Dec 16 09:13:38 GMT 2023 , Edited by admin on Sat Dec 16 09:13:38 GMT 2023
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DAILYMED
Y2KBV9FZ9M
Created by admin on Sat Dec 16 09:13:38 GMT 2023 , Edited by admin on Sat Dec 16 09:13:38 GMT 2023
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SMS_ID
100000135241
Created by admin on Sat Dec 16 09:13:38 GMT 2023 , Edited by admin on Sat Dec 16 09:13:38 GMT 2023
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