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Details

Stereochemistry RACEMIC
Molecular Formula C18H29N3O5
Molecular Weight 367.4407
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BAMBUTEROL

SMILES

CC(C)(C)NCC(c1cc(cc(c1)OC(=O)N(C)C)OC(=O)N(C)C)O

InChI

InChIKey=ANZXOIAKUNOVQU-UHFFFAOYSA-N
InChI=1S/C18H29N3O5/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7/h8-10,15,19,22H,11H2,1-7H3

HIDE SMILES / InChI

Description
Curator's Comment:: https://www.medicines.org.uk/emc/medicine/9574 | http://www.meppo.com/pdf/drugs/2596-BAMBEC-ORAL-SOLUTION-1427211370.pdf | https://www.ncbi.nlm.nih.gov/pubmed/2906603

Bambuterol is a remarkably selective and potent inhibitor of cholinesterase. BAMBEC (Bambuterol hydrochloride) oral solution or tablets are indicated for the management of asthma, bronchospasm and/or reversible airways obstruction.

CNS Activity

Curator's Comment:: Bambuterol distribution to CNS is negligible, however chronic, but not acute, treatment with bambuterol relieves allodynia in a murine model of neuropathy.

Originator

Curator's Comment:: # AB Draco (Subsidiary of AB Astra, now AstraZeneca)

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
BAMBEC

Approved Use

BAMBEC (Bambuterol hydrochloride) oral solution or tablets are indicated for the management of asthma, bronchospasm and/or reversible airways obstruction.
Primary
BAMBEC

Approved Use

BAMBEC (Bambuterol hydrochloride) oral solution or tablets are indicated for the management of asthma, bronchospasm and/or reversible airways obstruction.
PubMed

PubMed

TitleDatePubMed
Tremor in healthy volunteers after bambuterol and terbutaline CR-tablets.
1993
Bambuterol and terbutaline in human cerebrospinal fluid and plasma.
1993
Risk of non-fatal cardiac failure and ischaemic heart disease with long acting beta 2 agonists.
1998 Jul
Patents

Sample Use Guides

BAMBEC (Bambuterol hydrochloride) Tablets 10 mg. The recommended starting doses are 10 mg–20 mg. The 10 mg dose may be increased to 20 mg if necessary after 1–2 weeks, depending on the clinical effect. In patients who have previously tolerated beta2-agonists well, the recommended starting dose, as well as maintenance dose, is 20 mg.
Route of Administration: Oral
Name Type Language
BAMBUTEROL
INN   MI   WHO-DD  
INN  
Official Name English
BAMBUTEROL [INN]
Common Name English
BAMBUTEROL [WHO-DD]
Common Name English
(+/-)-5-(2-(TERT-BUTYLAMINO)-1-HYDROXYETHYL)-M-PHENYLENE BIS(DIMETHYLCARBAMATE)
Systematic Name English
BAMBUTEROL [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QR03CC12
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
WHO-ATC R03CC12
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
NCI_THESAURUS C48149
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
Code System Code Type Description
CAS
81732-65-2
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
WIKIPEDIA
BAMBUTEROL
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
EPA CompTox
81732-65-2
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
PUBCHEM
54766
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
FDA UNII
Y1850G1OVC
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
MERCK INDEX
M2216
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY Merck Index
ChEMBL
CHEMBL521589
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
DRUG CENTRAL
285
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
RXCUI
18751
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY RxNorm
IUPHAR
6601
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
EVMPD
SUB06095MIG
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
INN
5304
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
DRUG BANK
DB01408
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
MESH
C047766
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY
NCI_THESAURUS
C81692
Created by admin on Sat Jun 26 16:18:00 UTC 2021 , Edited by admin on Sat Jun 26 16:18:00 UTC 2021
PRIMARY