U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Corticorelin ovine is an analogue of the naturally occurring human corticotropin-releasing hormone (hCRH) peptide. Corticorelin ovine is a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. ACTH stimulates cortisol production from the adrenal cortex. Corticorelin ovine was marketed under the brand name ACTHREL for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing’s syndrome.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P34998
Gene ID: 104909134|||1394
Gene Symbol: CRHR1
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
ACTHREL

Approved Use

ACTHREL® is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing’s syndrome.

Launch Date

8.3272322E11

Sample Use Guides

A single intravenous dose of ACTHREL® (corticorelin ovine) at 1 mcg/kg is recommended for the testing of pituitary corticotrophin function. A dose of 1 mcg/kg is the lowest dose that produces maximal cortisol responses and significant (though apparently sub-maximal) ACTH responses. Doses above 1 mcg/kg are not recommended.
Route of Administration: Intravenous
Name Type Language
CORTICORELIN OVINE
VANDF  
Common Name English
CORTICORELIN OVINE [VANDF]
Common Name English
CORTICOTROPIN-RELEASING FACTOR (SHEEP)
Common Name English
OVINE CORTICOTROPIN-RELEASING FACTOR
Common Name English
OVINE CORTICOTROPIN-RELEASING HORMONE
Common Name English
CORTICORELIN (OVINE)
Common Name English
CORTICOTROPIN RELEASING FACTOR, OVINE
Common Name English
OVINE CORTICOTROPIN RELEASING FACTOR
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C394
Created by admin on Sat Jun 26 18:56:37 UTC 2021 , Edited by admin on Sat Jun 26 18:56:37 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C61690
Created by admin on Sat Jun 26 18:56:37 UTC 2021 , Edited by admin on Sat Jun 26 18:56:37 UTC 2021
PRIMARY
DRUG BANK
DB09067
Created by admin on Sat Jun 26 18:56:37 UTC 2021 , Edited by admin on Sat Jun 26 18:56:37 UTC 2021
PRIMARY
EPA CompTox
79804-71-0
Created by admin on Sat Jun 26 18:56:37 UTC 2021 , Edited by admin on Sat Jun 26 18:56:37 UTC 2021
PRIMARY
PUBCHEM
16132344
Created by admin on Sat Jun 26 18:56:37 UTC 2021 , Edited by admin on Sat Jun 26 18:56:37 UTC 2021
PRIMARY
FDA UNII
Y124TZ0513
Created by admin on Sat Jun 26 18:56:37 UTC 2021 , Edited by admin on Sat Jun 26 18:56:37 UTC 2021
PRIMARY
DRUG CENTRAL
5195
Created by admin on Sat Jun 26 18:56:37 UTC 2021 , Edited by admin on Sat Jun 26 18:56:37 UTC 2021
PRIMARY
CAS
79804-71-0
Created by admin on Sat Jun 26 18:56:37 UTC 2021 , Edited by admin on Sat Jun 26 18:56:37 UTC 2021
PRIMARY
RXCUI
74671
Created by admin on Sat Jun 26 18:56:37 UTC 2021 , Edited by admin on Sat Jun 26 18:56:37 UTC 2021
PRIMARY RxNorm