DICARBINE

Details

Stereochemistry	MIXED
Molecular Formula	C13H18N2
Molecular Weight	202.2954
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC2NC3=C(C=C(C)C=C3)C2C1

InChI

InChIKey=CYJQCYXRNNCURD-UHFFFAOYSA-N

InChI=1S/C13H18N2/c1-9-3-4-12-10(7-9)11-8-15(2)6-5-13(11)14-12/h3-4,7,11,13-14H,5-6,8H2,1-2H3

HIDE SMILES / InChI

Description
Sources: http://www.genmed.ru/med_r14_534_03.html

Dicarbine is an orally active drug approved in Russia under the trade name Карбидин, is used for the treatment patients with schizophrenia and alcoholic psychosis. This drug blocks dopamine receptors in various brain parts, which leads to a reduction in the productive symptoms of psychosis: delusions and hallucinations.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine receptor 60 Target ID: CHEMBL2096905 Sources: http://www.genmed.ru/med_r14_534_03.html	Blocker 537

Conditions

Condition	Modality	Targets	Highest Phase	Product
Schizophrenia 298 Sources: http://www.genmed.ru/med_r14_534_03.html	Primary		Not Provided 504	Unknown Approved Use Unknown
Alcoholic psychosis 1 Sources: http://www.genmed.ru/med_r14_534_03.html	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Effect of the atypical neuroleptics carbidine and sulpiride on dopamine biosynthesis in the synaptosomes of the nucleus accumbens septi in rats].	1987 Mar-Apr	2884129
Processes linked to the formation of reactive oxygen species are not necessarily involved in the development of isoproterenol-induced hypertrophy of the heart. The effect of stobadine.	1991	1840475
Free radical-induced protein modification and inhibition of Ca2+-ATPase of cardiac sarcoplasmic reticulum.	2003 Jun	12870653
Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells.	2007 Sep	17481927

Sample Use Guides

In Vivo Use Guide

oral: schizophrenia: for adults: the initial dose of 12.5 mg to 50-75 mg, in some cases up to 400-600 mg/ day in 3 admissions. oral: alcoholic psychosis: 50 mg 3-4 times/day, intervals of 2 hours.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

DICARBINE

Official Name

English

2,3,4,4A,5,9B-HEXAHYDRO-2,8-DIMETHYL-1H-PYRIDO(4,3-B)INDOLE

Common Name

English

1H-PYRIDO(4,3-B)INDOLE, 2,3,4,4A,5,9B-HEXAHYDRO-2,8-DIMETHYL-

Common Name

English

dicarbine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C275