SUCRALFATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H30Al8O51S8.H2O.AlH3O3
Molecular Weight	1558.727
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O[Al](O)O.[H][C@]2(O[C@]1(COS(=O)(=O)O[Al](O)O)O[C@H](COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@@H]1OS(=O)(=O)O[Al](O)O)O[C@H](COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@H]2OS(=O)(=O)O[Al](O)O

InChI

InChIKey=IPLJAZDIICJQEL-JTJNLBSYSA-A

InChI=1S/C12H22O35S8.9Al.20H2O/c13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/h4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;;;;;;;;;20*1H2/q;9*+3;;;;;;;;;;;;;;;;;;;;/p-27/t4-,5-,6-,7-,8+,9-,10+,11-,12+;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/m1............................./s1

HIDE SMILES / InChI

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/018333s034,019183s016lbl.pdf
Curator's Comment: description was created based on several sources, including https://www.drugs.com/pro/sucralfate.html | https://www.ncbi.nlm.nih.gov/pubmed/8944383

Sucralfate (trade name CARAFATE) is a medication primarily taken to treat active duodenal ulcers. Sucralfate is also used for the treatment of gastroesophageal reflux disease (GERD) and stress ulcers. Sucralfate is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus. Sucralfate is only minimally absorbed from the gastrointestinal tract. The small amounts of the sulfated disaccharide that are absorbed are excreted primarily in the urine.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
degradation of mucus 1 Target ID: degradation of mucus Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/018333s034,019183s016lbl.pdf	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Ulcer 5 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/018333s034,019183s016lbl.pdf	Primary		Approved 8429	CARAFATE Approved Use Sucralfate is indicated in: Short-term treatment (up to 8 weeks) of active duodenal ulcer. While healing with sucralfate may occur during the first week or two, treatment should be continued for 4 to 8 weeks unless healing has been demonstrated by x-ray or endoscopic examination. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of acute ulcers. Launch Date 1981

C_max

Value	Dose	Co-administered	Analyte	Population
1.27 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9257738/	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:		SUCRALFATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
35 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9257738/	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:		SUCRALFATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
20 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9257738/	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:		SUCRALFATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

Doses

Dose	Population	Adverse events
3 g single, topical Dose: 3 g Route: topical Route: single Dose: 3 g Sources: https://pubmed.ncbi.nlm.nih.gov/21552054/	healthy, 23 years (range: 17–49 years) n = 39 Health Status: healthy Age Group: 23 years (range: 17–49 years) Sex: M+F Population Size: 39 Sources: https://pubmed.ncbi.nlm.nih.gov/21552054/	Sources: https://pubmed.ncbi.nlm.nih.gov/21552054/

PubMed

Title	Date	PubMed
Experimental study of sucralfate intervention for paraquat poisoning in rats.	2017 Jul	28501785

Patents

Sample Use Guides

In Vivo Use Guide

The recommended adult oral dosage for duodenal ulcer is 1 g (10 mL/2 teaspoons) four times per day. CARAFATE should be administered on an empty stomach.

Route of Administration: Oral

In Vitro Use Guide

For sustained release of sucralfate and bFGF, implants were coated with hydron. Suspension no. 1 contained 100 ml of 95% ethanol mixed with 0.12 mg/ml of hydron. Next, 60 ml of premixed suspension no. 1 was prepared with 10 mg/ml of sucralfate. Then, 20 ml of premixed suspension no. 2 was mixed with 12 ng/ml of bFGF, which was prepared with 100 jul of sterile saline. Finally, implants were dipped into the suspension for 5 min and then dried for 8 h before being placed in the media in sterile Petri dishes.

Name

Type

Language

SUCRALFATE

Official Name

English

ULCAR

Brand Name

English

ALUMINUM SUCROSE OCTASULFATE [INCI]

Common Name

English

ANTEPSIN

Brand Name

English

VENTER

Brand Name

English

SULCRATE

Brand Name

English

SUCROSE OCTAKIS(HYDROGEN SULFATE) ALUMINIUM COMPLEX

Common Name

English

ULCERMIN

Brand Name

English

SUCRALFIN

Brand Name

English

SUGAST

Brand Name

English

SUCRALFATE HYDRATE [JAN]

Common Name

English

.BETA.-D-FRUCTOFUCANOSYL-.ALPHA.-D-GLUCOPYRANOSIDE OCTAKIS(HYDROGEN SULPHATE)ALUMINUM COMPLEX

Common Name

English

SUCCOSA

Brand Name

English

SUCRALFATE [ORANGE BOOK]

Common Name

English

HEXADECA-.MU.-HYDROXYTETRACOSAHYDROXY(.MU.8-(1,3,4,6-TETRA-O-SULFO-.BETA.-DFRUCTOFURANOSYL-.ALPHA.-D-GLUCOPYRANOSIDE TETRAKIS(HYDROGEN SULFATO)8-)))HEXADECAALUMINUM

Common Name

English

SUCRALFATE [MART.]

Common Name

English

ALUMINUM SUCROSE OCTASULFATE

Official Name

English

ALUMINIUM, HEXADECA-.MU.-HYDROXYTETRACOSAHYDROXY(.MU.8-(1,3,4,6-TETRA-O-SULFO-.BETA.-D-FRUCTOFURANOSYL .ALPHA.-D-GLUCOPYRANOSIDE TETRAKIS(HYDROGEN SULFATO)(8-)))HEXADECA-

Common Name

English

ULCOGANT

Brand Name

English

SUCRALFATE [EP MONOGRAPH]

Common Name

English

sucralfate [INN]

Common Name

English

.BETA.-D-FRUCTOFUCANOSYL-.ALPHA.-D-GLUCOPYRANOSIDE OCTAKIS(HYDROGEN SULFATE)ALUMINIUM COMPLEX

Common Name

English

SUCRALFATE [MI]

Common Name

English

CITOGEL

Brand Name

English

HEXAGASTRON

Brand Name

English

SUCRALFATE HYDRATE

Common Name

English

.BETA.-D-FRUCTOFUCANOSYL-.ALPHA.-D-GLUCOPYRANOSIDE OCTAKIS(HYDROGEN SULFATE)ALUMINUM COMPLEX

Common Name

English

KEAL

Brand Name

English

SUCRALFATE [VANDF]

Common Name

English

HEXADECA-.MU.-HYDROXYTETRACOSAHYDROXY(.MU.8-(1,3,4,6-TETRA-O-SULFO-.BETA.-DFRUCTOFURANOSYL-.ALPHA.-D-GLUCOPYRANOSIDE TETRAKIS(HYDROGEN SULFATO)8-)))HEXADECAALUMINIUM

Common Name

English

SUCRATE

Brand Name

English

Sucralfate [WHO-DD]

Common Name

English

ULSANIC

Brand Name

English

SUCRALFATE [USAN]

Common Name

English

CARAFATE

Brand Name

English

SUCRALFATE [HSDB]

Common Name

English

SUCROSE OCTAKIS(HYDROGEN SULPHATE) ALUMINUM COMPLEX

Common Name

English

Sucrose octakis(hydrogen sulfate) aluminum complex

Common Name

English

URBAL

Brand Name

English

SUCRALFATE [USP MONOGRAPH]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C797