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Details

Stereochemistry RACEMIC
Molecular Formula C12H18Cl2N2O
Molecular Weight 277.19
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLENBUTEROL

SMILES

CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1

InChI

InChIKey=STJMRWALKKWQGH-UHFFFAOYSA-N
InChI=1S/C12H18Cl2N2O/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7/h4-5,10,16-17H,6,15H2,1-3H3

HIDE SMILES / InChI

Description

Clenbuterol is agonist of beta2 adrenergic receptor. In some countries it is used as bronchodilator for treatment of asthma, but is not approved in USA. The drug is abused by bodybuilders and athletes for its ability to increase lean muscle mass and to reduce body fat. In 1998 FDA approved the clenbuterol-based Ventipulmin Syrup as a prescription-only drug for treatment of airway obstruction in horses.

CNS Activity

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
570.0 nM [Ki]
Conditions
PubMed

PubMed

TitleDatePubMed
[Novel quantitative assessment of the tremorogenic effects of the beta 2-mimetics clenbuterol and salbutamol after oral administration].
1985
Is the "atypical" beta-receptor in the rat stomach fundus the rat beta 3 receptor?
1995 Jan
Adrenergic agents inhibit rapid increases in cerebellar Purkinje cell glutamic acid decarboxylase (GAD67) mRNA levels after climbing fiber lesions or reserpine treatment.
1996 Mar 1
Clenbuterol and anabolic steroids: a previously unreported cause of myocardial infarction with normal coronary arteriograms.
1998 Aug
Solid substrate-room temperature phosphorimetry for the determination of residual clenbuterol hydrochloride based on the catalysis of sodium periodate oxidizing eosine Y.
2009 Apr 6
Accumulation of the beta(2)-adrenergic agonist clenbuterol in mouse dark hair.
2009 Nov
Beta2-adrenergic agonist-induced hypertrophy of the quadriceps skeletal muscle does not modulate disease severity in the rodent meniscectomy model of osteoarthritis.
2010 Apr
Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats.
2010 Jul
Antitussive effects of the leukotriene receptor antagonist montelukast in patients with cough variant asthma and atopic cough.
2010 Jun
Blocking beta2-adrenergic receptor attenuates acute stress-induced amyloid beta peptides production.
2010 Mar 4
Patents

Sample Use Guides

In Vivo Use Guide
For treatmen of airways obstruction the clenbuterol is administered orally, 15ml of syrop 2-3 times a day.
Route of Administration: Oral
In Vitro Use Guide
Affinity towards beta2 adrenergic receptors was measured using the recombinant receptor expressed in Sf-9 cells. Cell membrane homogenates were incubated with 0.15 nM of radioligand [3H]CGP1217 in the absence of presence of the clenbuterol. Following incubation, the samples were filtered rapidly under vacuum through through glass fiber filters, the filters were dried, and counted for radioactivity in a scintillation counter. Clenbuterol was binding to beta2 receptor with Ki of 0.58 uM.
Name Type Language
CLENBUTEROL
INN   MI   WHO-DD  
INN  
Official Name English
CLENBUTEROL [MI]
Common Name English
CLENBUTEROL [WHO-DD]
Common Name English
CLENBUTEROL [INN]
Common Name English
PLANIPART
Brand Name English
NAB 365
Code English
CONTRASPASMIN
Brand Name English
Classification Tree Code System Code
WHO-VATC QR03CC13
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
WHO-VATC QR03AC14
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
WHO-VATC QR03CC90
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
WHO-ATC R03CC13
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
CFR 21 CFR 530.41
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
CFR 21 CFR 520.452
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
WHO-ATC R03AC14
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
WHO-VATC QG02CA91
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
Code System Code Type Description
EVMPD
SUB06651MIG
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY
CAS
37148-27-9
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY
MESH
D002976
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY
EPA CompTox
37148-27-9
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY
PUBCHEM
2783
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY SWITZERF
INN
3264
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY
WIKIPEDIA
CLENBUTEROL
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY
DRUG BANK
DB01407
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY
RXCUI
2580
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY RxNorm
MERCK INDEX
M3615
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY Merck Index
ECHA (EC/EINECS)
253-366-0
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY
ChEMBL
CHEMBL49080
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY
NCI_THESAURUS
C65335
Created by admin on Tue Mar 06 11:44:29 UTC 2018 , Edited by admin on Tue Mar 06 11:44:29 UTC 2018
PRIMARY