Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H23NO3.C4H6O4 |
| Molecular Weight | 431.4789 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCC(O)=O.CCOC1=C(O[C@H]([C@@H]2CNCCO2)C3=CC=CC=C3)C=CC=C1
InChI
InChIKey=YXZTUOWIYOESGT-HLRBRJAUSA-N
InChI=1S/C19H23NO3.C4H6O4/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;5-3(6)1-2-4(7)8/h3-11,18-20H,2,12-14H2,1H3;1-2H2,(H,5,6)(H,7,8)/t18-,19-;/m0./s1
Esreboxetine (PNU-165442G) is the (S,S)-(+)-enantiomer of antidepressant reboxetine, a selective norepinephrine reuptake inhibitor. The (S,S)-enantiomer is a more potent inhibitor of norepinephrine transporter than (R,R)-enantiomer. Esreboxetine was being developed by Pfizer, primarily for the treatment of fibromyalgia.
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152). | 2011-10-13 |
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| Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. | 2011 |
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| [Postoperative pain after transvaginal repair of pelvic organ prolapse with or without mesh]. | 2010-11 |
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| Pelvic magnetic resonance imaging for assessment of the efficacy of the Prolift system for pelvic organ prolapse. | 2010-11 |
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| Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials. | 2010-10-12 |
|
| [Patent for medical device: from design to marketing (example of Prolift®)]. | 2010-10 |
|
| Transurethral and suprapubic mesh resection after Prolift bladder perforation: a case report. | 2010-10 |
|
| Now or later...Does timing of a midurethral sling in relation to transvaginal prolapse repair affect continence outcomes at 1 year? | 2010-09 |
|
| Vaginal hysterectomy at the time of transvaginal mesh placement. | 2010-09 |
|
| [Transvaginal repair of genital prolapse using the Prolift technique: a prospective study]. | 2010-09 |
|
| Permeation of chlorothalonil through nitrile gloves: collection solvent effects in the closed-loop permeation method. | 2010-07-15 |
|
| Midterm prospective evaluation of TVT-Secur reveals high failure rate. | 2010-07 |
|
| Mid-term results of pelvic organ prolapse repair using a transvaginal mesh: the experience in Sherbooke, Quebec. | 2010-06 |
|
| Optimal primary minimally invasive treatment for patients with stress urinary incontinence and symptomatic pelvic organ prolapse: tension free slings with colporrhaphy, or Prolift with the tension free midurethral sling? | 2010-05 |
|
| [Changes in the length of implanted mesh after reconstructive surgery of the anterior vaginal wall]. | 2010-04 |
|
| [Prolene mesh comparing with sacrospinal fixation in the treatment of genital prolapse in women. Prospective multicentre randomized study]. | 2010-04 |
|
| [Correlation between stress urinary incontinence or urgency and anterior compartment defect before and after surgical treatment]. | 2010-04 |
|
| Transvaginal mesh repair of anterior and posterior vaginal wall prolapse: a clinical and ultrasonographic study. | 2010-04 |
|
| Successful management of depression with reboxetine in a patient who developed Parkinsonism related to paroxetine use. | 2010-04 |
|
| Anatomical and functional outcomes of posterior intravaginal slingplasty for the treatment of vaginal vault or uterine prolapse: a prospective, multicenter study. | 2010-03 |
|
| Does trocar-guided tension-free vaginal mesh (Prolift) repair provoke prolapse of the unaffected compartments? | 2010-03 |
|
| Permeation of herbicidal dichlobenil from a Casoron formulation through nitrile gloves. | 2010-02 |
|
| One-year outcome of concurrent anterior and posterior transvaginal mesh surgery for treatment of advanced urogenital prolapse: case series. | 2009-11-16 |
|
| Laparoscopic sacrohysteropexy and myomectomy for uterine prolapse: a case report and review of the literature. | 2009-11-03 |
|
| [Clinical observation on quality of life of two different operative methods of total pelvic floor reconstruction.]. | 2009-11 |
|
| A serious complication following placement of posterior Prolift. | 2009-11 |
|
| Anatomic outcomes of vaginal mesh procedure (Prolift) compared with uterosacral ligament suspension and abdominal sacrocolpopexy for pelvic organ prolapse: a Fellows' Pelvic Research Network study. | 2009-11 |
|
| Synthetic graft use in vaginal prolapse surgery: objective and subjective outcomes. | 2009-11 |
|
| Short term impact on female sexual function of pelvic floor reconstruction with the Prolift procedure. | 2009-11 |
|
| Trocar-guided total tension-free vaginal mesh repair of post-hysterectomy vaginal vault prolapse. | 2009-10 |
|
| Laparoscopic apical mesh excision for deep dyspareunia caused by mesh banding in the vaginal apex. | 2009-09 |
|
| De novo stress incontinence and pelvic muscle symptoms after transvaginal mesh repair. | 2009-07 |
|
| Changes in levator ani muscle after vaginal hysterectomy and prolapse repair using the Total Prolift procedure. | 2009-07 |
|
| [Transvaginal repair of genital prolapse with prolift: a standardized surgery?]. | 2009-04 |
|
| Perineal approach to vascular anatomy during transobturator cystocele repair. | 2009-04 |
|
| [Choice of a surgical treatment of genital prolapse in women]. | 2009-03-03 |
|
| [Transvaginal repair of genital prolapse with Prolift: evaluation of safety and learning curve]. | 2009-02 |
|
| Implants in operative therapy in women with pelvic organ prolapse--two years of experience. | 2009 |
|
| Vaginal vault prolapse. | 2009 |
|
| Vaginal repair of cystocele with anterior wall mesh via transobturator route: efficacy and complications with up to 3-year followup. | 2009 |
|
| [Surgical treatment of female pelvic organ prolapse at the Clinic of Obstetrics and Gynecology, Hospital of Kaunas University of Medicine]. | 2009 |
|
| Psychopharmacology of ADHD in pediatrics: current advances and issues. | 2009 |
|
| The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression. | 2009 |
|
| Outcome of treatment of anterior vaginal wall prolapse and stress urinary incontinence with transobturator tension-free vaginal mesh (prolift) and concomitant tension-free vaginal tape-obturator. | 2009 |
|
| Total Prolift System surgery for treatment posthysterectomy vaginal vault prolapse--do we treat both anatomy and function? | 2008-12 |
|
| [Clinical study on concomitant surgery for stress urinary incontinence and pelvic organ prolapse]. | 2008-10-15 |
|
| [Occult stress incontinence identified by preoperative urodynamic study in women with severe pelvic organ prolapse]. | 2008-09 |
|
| Fixed combinations in the management of hypertension: perspectives on lercanidipine-enalapril. | 2008 |
|
| Efficacy and tolerability of reboxetine compared with imipramine in a double-blind study in patients suffering from major depressive offsodes. | 1997-04 |
|
| Pharmacokinetics of reboxetine in healthy volunteers. Single oral doses, linearity and plasma protein binding. | 1995-08 |
Patents
| Name | Type | Language | ||
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Preferred Name | English | ||
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Official Name | English | ||
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Common Name | English | ||
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Code | English | ||
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C265
Created by
admin on Mon Mar 31 18:31:02 GMT 2025 , Edited by admin on Mon Mar 31 18:31:02 GMT 2025
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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100000127897
Created by
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SUB34044
Created by
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DTXSID10979793
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TT-90
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CHEMBL180101
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24754241
Created by
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635724-55-9
Created by
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XQO13W6OCH
Created by
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C87613
Created by
admin on Mon Mar 31 18:31:02 GMT 2025 , Edited by admin on Mon Mar 31 18:31:02 GMT 2025
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
