METAZOCINE

Description
Sources: https://pubs.acs.org/doi/10.1021/jo01362a017 | https://www.law.cornell.edu/cfr/text/21/1308.12 | https://www.ncbi.nlm.nih.gov/pubmed/3786338 | https://www.ncbi.nlm.nih.gov/pubmed/1322987 | https://www.ncbi.nlm.nih.gov/pubmed/12437765 | https://www.ncbi.nlm.nih.gov/pubmed/12513698 | https://www.ncbi.nlm.nih.gov/pubmed/16433932 | https://www.ncbi.nlm.nih.gov/pubmed/1846412 | https://www.ncbi.nlm.nih.gov/pubmed/1331411

Metazocine is a synthetic opioid analgesic with reinforcing properties and PCP-like activity. Metazocine is a Schedule II controlled substance. Metazocine acts as a ligand at opioid, sigma and NMDA receptors. Metazocine enantiomers exert different pharmacological activity.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Activation profiles of opioid ligands in HEK cells expressing delta opioid receptors.	2002 Nov 18	12437765
Activity of opioid ligands in cells expressing cloned mu opioid receptors.	2003 Jan 4	12513698
Migratory hydroamination: a facile enantioselective synthesis of benzomorphans.	2003 Jul 23	12862467
Pharmacological profiles of opioid ligands at kappa opioid receptors.	2006 Jan 25	16433932
Catalytic enantioselective amination of silyl enol ethers using chiral dirhodium(II) carboxylates: asymmetric formal synthesis of (-)-metazocine.	2007 Oct 25	17894504

Patents

Name

Type

Language

METAZOCINE

Official Name

English

METAZOCINE, (±)-

Common Name

English

METAZOCINE [MI]

Common Name

English

1,2,3,4,5,6-HEXAHYDRO-3,6,11-TRIMETHYL-2,6-METHANO-3-BENZAZOCIN-8-OL

Common Name

English

1,2,3,4,5,6-HEXAHYDRO-8-HYDROXY-3,6,11-TRIMETHYL-2,6-METHANO-3-BENZAZOCINE

Common Name

English

2,6-METHANO-3-BENZAZOCIN-8-OL, 1,2,3,4,5,6-HEXAHYDRO-3,6,11-TRIMETHYL-

Systematic Name

English

METHOBENZMORPHAN

Common Name

English

metazocine [INN]

Common Name

English

2'-HYDROXY-2,5,9-TRIMETHYL-6,7-BENZOMORPHAN

Common Name

English

IDS-NM-001

Code

English

Classification Tree Code System Code

DEA NO.

9240