FONAZINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H25N3O2S2.ClH
Molecular Weight	428.012
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)S(=O)(=O)N(C)C)N(C)C

InChI

InChIKey=YKXZRFSKLBBPQN-UHFFFAOYSA-N

InChI=1S/C19H25N3O2S2.ClH/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5;/h6-12,14H,13H2,1-5H3;1H

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Description
Sources: http://www.mufel.net/plm05/6816.htm
Curator's Comment: description was created based on several sources, including, https://www.jstage.jst.go.jp/article/gnam1977/3/2/3_113/_pdf, http://www.ncbi.nlm.nih.gov/pubmed/8564192

Fonzine (also known as dimetotiazine) is an analgesics and anti-inflammatory agent marketed in Japan and Europe under the name Migristene and indicated for the treatment of migraine and headaches secondary to other disease. Fonzine exerts its activity by inhibiting serotonin and histamine H1 receptors.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin (5-HT) receptor 34 Target ID: CHEMBL2096904 Sources: https://www.jstage.jst.go.jp/article/gnam1977/3/2/3_113/_pdf	Antagonist 2778
Histamine H1 receptor 315 Target ID: P35367 Gene ID: 3269.0 Gene Symbol: HRH1 Target Organism: Homo sapiens (Human) Sources: http://www.ncbi.nlm.nih.gov/pubmed/8564192	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Migraine 103 Sources: http://www.mufel.net/plm05/6816.htm	Primary		Approved 8429	MIGRISTENE Approved Use Prophylactic and curative treatment of migraine and headaches secondary other diseases.
Secondary headache 3 Sources: http://www.mufel.net/plm05/6816.htm	Primary		Approved 8429	MIGRISTENE Approved Use Prophylactic and curative treatment of migraine and headaches secondary other diseases.

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Take 20-80 mg during the first day (2-4 tablets) and then - 40 mg/day (2 tablets) up to 3 months.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

FONAZINE HYDROCHLORIDE

Common Name

English

FONAZINE HYDROCHLORIDE [MI]

Common Name

English

DIMETHOTHIAZINE MONOHYDROCHLORIDE

Common Name

English

10H-PHENOTHIAZINE-2-SULFONAMIDE, 10-(2-(DIMETHYLAMINO)PROPYL)-N,N-DIMETHYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

251-996-0