Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C26H28N4O |
Molecular Weight | 412.5267 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CO[C@H]1CC[C@@]2(CC3=C(C=C(C=C3)C4=CC(=CN=C4)C#CC)[C@@]25N=C(C)C(N)=N5)CC1
InChI
InChIKey=WKDNQONLGXOZRG-HRNNMHKYSA-N
InChI=1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,(H2,27,30)/t22-,25-,26-/m0/s1
AZD-3293 camsylate wider known as Lanabecestat camsylate, a salt of Lanabecestat, a drug that was invented for the treatment of Alzheimer's disease. Lanabecestat inhibits beta-secretase 1 cleaving enzyme (BACE1) thus preventing the buildup of beta-amyloid and help stop the progression of Alzheimer's disease. The drug was in phase III clinical trials, but studies were discontinued because of recommendations by an independent data monitoring committee (IDMC). IDMC concluded that all trials, in early Alzheimer’s disease, and in mild Alzheimer’s disease dementia, were not likely to meet their primary endpoints upon completion and therefore should be stopped for futility.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P56817|||Q9UJT5 Gene ID: 23621.0 Gene Symbol: BACE1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/27418961 |
0.4 nM [Ki] |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT02245737
Lanabecestat (AZD3293) 20 milligrams (mg) given orally once daily for 104 weeks
Route of Administration:
Oral
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C170091
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10530
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67979346
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DE-76
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100000177234
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DB14814
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AZD3293
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DTXSID401032008
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1383984-21-1
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1383982-64-6
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X8SPJ492VF
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)