Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H18FN3O2 |
| Molecular Weight | 326.3554 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC1=CC=C(C=N1)C2=NC3=C(C=C2)C=C(OC[C@H](O)C[18F])C=C3
InChI
InChIKey=DLVXFZWSPCOWSN-DHZJDKHOSA-N
InChI=1S/C18H18FN3O2/c1-20-18-7-3-13(10-21-18)17-5-2-12-8-15(4-6-16(12)22-17)24-11-14(23)9-19/h2-8,10,14,23H,9,11H2,1H3,(H,20,21)/t14-/m1/s1/i19-1
18F-THK-5351 is a novel radiotracer that demonstrates high binding selectivity and affinity for tau pathology and exhibits better pharmacokinetics in the living brain than previous THK tau probes. FluoroTau is in phase II clinical trials as a positron emission tomography (PET) imaging agent for the diagnosis and monitoring of the progression of Alzheimer's disease(AD) in South Korea.
This compound was originally discovered by Tohoku University, and now is being developed by GE Healthcare, Samung Medical Centre and Asan Medical Center.
Approval Year
Sample Use Guides
18F-THK-5351 radiotracer was injected through a venous line into the arm of 12
subjects with a mean administered activity of 377.8 +/-14.0 MBq. The scanning
protocol included 1–2 min emission scans for four cycles at 10, 60, 120, and 240
min post-injection. Each cycle consisted of seven bed positions, thus the
whole-body scanning time was 10 min per cycle.
Route of Administration:
Intravenous
In Vitro Use Guide
Curator's Comment: In vitro saturation binding assays were conducted to measure
the binding affinity of 18F-THK5351 for postmortem tissues from
AD patients.
18F-THK5351 bound to AD hippocampal
homogenates with high affinity (Kd 5 2.9 nmol/L; maximum
number of binding sites =368.3 pmol/g tissue).
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1707148-68-2
Created by
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X7F1935FL1
Created by
admin on Sat Dec 16 11:19:16 GMT 2023 , Edited by admin on Sat Dec 16 11:19:16 GMT 2023
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91810702
Created by
admin on Sat Dec 16 11:19:16 GMT 2023 , Edited by admin on Sat Dec 16 11:19:16 GMT 2023
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ACTIVE MOIETY
