Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H6N2O3 |
| Molecular Weight | 190.1555 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[O-][N+](=O)C1=C2C=CC=CC2=[N+]([O-])C=C1
InChI
InChIKey=YHQDZJICGQWFHK-UHFFFAOYSA-N
InChI=1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| p53 protein activates the transcription of human proliferating cell nuclear antigen in response to 4-nitroquinoline N-oxide treatment. | 2005-02 |
|
| Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. | 2005-01-05 |
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| Differential regulation of gene expression by RNA polymerase II in response to DNA damage. | 2004-12-17 |
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| Suppressive effects of a selective cyclooxygenase-2 inhibitor, etodolac, on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. | 2004-12 |
|
| Therapeutic efficacy of green tea polyphenols on cellular thiols in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis. | 2004-10-15 |
|
| Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping. | 2004-10-08 |
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| Ectopic expression of tyrosinase increases melanin synthesis and cell death following UVB irradiation in fibroblasts from familial atypical multiple mole and melanoma (FAMMM) patients. | 2004-10 |
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| Genomic instability in non-neoplastic oral mucosa cells can predict risk during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. | 2004-10 |
|
| The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA. | 2004-08 |
|
| High frequency methylation of p16INK4A gene during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. | 2004-07 |
|
| The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. | 2004-06-03 |
|
| Effects of genotoxic compounds on DNA and development of early and late grass shrimp embryo stages. | 2004-06 |
|
| On the relevance of genotoxicity for fish populations II: genotoxic effects in zebrafish (Danio rerio) exposed to 4-nitroquinoline-1-oxide in a complete life-cycle test. | 2004-05-28 |
|
| On the relevance of genotoxicity for fish populations I: effects of a model genotoxicant on zebrafish (Danio rerio) in a complete life-cycle test. | 2004-05-28 |
|
| Apple phytochemicals and their health benefits. | 2004-05-12 |
|
| Genotoxicity of tamoxifen citrate and 4-nitroquinoline-1-oxide in the wing spot test of Drosophila melanogaster. | 2004-05 |
|
| Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair. | 2004-04 |
|
| Enhanced stimulation of chromosomal translocations by radiomimetic DNA damaging agents and camptothecin in Saccharomyces cerevisiae rad9 checkpoint mutants. | 2004-03-22 |
|
| Investigation of the antimutagenic effects of selected South African medicinal plant extracts. | 2004-02 |
|
| The Neurospora crassa mus-19 gene is identical to the qde-3 gene, which encodes a RecQ homologue and is involved in recombination repair and postreplication repair. | 2004-02 |
|
| Dietary protocatechuic acid during the progression phase exerts chemopreventive effects on chemically induced rat tongue carcinogenesis. | 2004-01-20 |
|
| Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice. | 2004-01-01 |
|
| A p53-independent pathway regulates nucleolar segregation and antigen translocation in response to DNA damage induced by UV irradiation. | 2004-01-01 |
|
| Anti-stress activity of Propionibacterium freudenreichii : identification of a reactivative protein. | 2004-01 |
|
| Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers. | 2004-01 |
|
| Transgenerational transmission of radiation- and chemically induced tumors and congenital anomalies in mice: studies of their possible relationship to induced chromosomal and molecular changes. | 2004 |
|
| A yeast-based method for the detection of cyto and genotoxicity. | 2003-11-06 |
|
| p53 haploinsufficiency profoundly accelerates the onset of tongue tumors in mice lacking the xeroderma pigmentosum group A gene. | 2003-11 |
|
| Recombinogenic effects of DNA-damaging agents are synergistically increased by transcription in Saccharomyces cerevisiae. New insights into transcription-associated recombination. | 2003-10 |
|
| Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. | 2003-10 |
|
| Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas of the tongue in rats initiated with 4-nitroquinoline 1-oxide. | 2003-09-25 |
|
| Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks. | 2003-08-01 |
|
| [Heat shock inhibits the induced expression of the SOS genes and SoxRS regulons in Escherichia coli]. | 2003-08 |
|
| The Schizosaccharomyces pombe cdt2(+) gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication. | 2003-07 |
|
| Correlation of P-cadherin and beta-catenin expression and phosphorylation with carcinogenesis in rat tongue cancer induced with 4-nitroquinoline 1-oxide. | 2003-07 |
|
| Histomorphologic and morphometric changes in minor salivary glands of the rat tongue during 4-nitroquinoline-1-oxide-induced carcinogenesis. | 2003-07 |
|
| [Erythroid differentiation of K562 cells resistant to 2-(4'-dimethylaminostyryl)quinoline 1-oxide or 4-nitroquinoline 1-oxide is significantly increased after thymidine treatment]. | 2003-06-21 |
|
| Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays. | 2003-04-20 |
|
| Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor gamma ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide. | 2003-04 |
|
| Antimutagenic effects of doenjang (Korean fermented soypaste) and its active compounds. | 2003-03-12 |
|
| Modulation of mutagenicity of various mutagens by lignin derivatives. | 2003-03-03 |
|
| Antimutagenic activity of extracts of natural substances in the Salmonella/microsome assay. | 2003-03 |
|
| Mutagenicity of the oral carcinogen 4-nitroquinoline-1-oxide in cultured BigBlue rat tongue epithelial cells and fibroblasts. | 2003-01-28 |
|
| Oral mucosal carcinogenesis in SENCAR mice. | 2003-01-18 |
|
| Effects of long-term administration of cancer-promoting substances on oral subepithelial mast cells in the rat. | 2003-01-18 |
|
| A novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue. | 2003 |
|
| Lactic acid bacteria isolated from dairy products inhibit genotoxic effect of 4-nitroquinoline-1-oxide in SOS-chromotest. | 2002-12 |
|
| Expression of beta-catenin in rat oral epithelial dysplasia induced by 4-nitroquinoline 1-oxide. | 2002-12 |
|
| Skeletal muscle regeneration associated with the stroma reaction during tumor invasion in the rat tongue. | 2002-10 |
|
| [Ultramicrostructural observation on epithelial cell disdifferentiation in rat tongue carcinogenesis induced by 4NQO]. | 2001-03 |
Patents
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| Classification Tree | Code System | Code | ||
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EPA PESTICIDE CODE |
600010
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52002-25-2
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16907
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4316
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4-NITROQUINOLINE 1-OXIDE
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56-57-5
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DTXSID5025780
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300000053029
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X5081510EV
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200-281-1
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19645
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5955
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SUBSTANCE RECORD
