Lepodisiran

Approval Year

Name

Type

Language

Lepodisiran

Official Name

English

LY-3819469 FREE ACID

Code

English

duplex of all-P-ambo-4′-de(hydroxymethyl)-4′-[(hydroxymethylphosphinoyl)methoxy]-2′-O-methylthiouridylyl-2′-deoxy-2′-fluorothioadenylyl-(3'→5')-2′-deoxy-2′-fluorothioguanylyl-(3'→5')-2′-deoxy-2′-fluoroadenylyl-(3'→5')-2′-deoxy-

Common Name

English

RNA, ([4′-de(hydroxymethyl)-4′-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2′-deoxy-2′-fluoro)A-sp-(2′-deoxy-2′-fluoro)G-sp-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)A-Cm-Cm-(2′-deoxy-2′-fluoro)A-Am-Gm-

Common Name

English

LY3819469 FREE ACID

Code

English

LEPODISIRAN [USAN]

Common Name

English

Code System Code Type Description

INN

13068

Created by admin on Sat Dec 16 19:10:07 GMT 2023 , Edited by admin on Sat Dec 16 19:10:07 GMT 2023

PRIMARY

USAN

LM-86

Created by admin on Sat Dec 16 19:10:07 GMT 2023 , Edited by admin on Sat Dec 16 19:10:07 GMT 2023

PRIMARY

CAS

2808361-18-2

Created by admin on Sat Dec 16 19:10:07 GMT 2023 , Edited by admin on Sat Dec 16 19:10:07 GMT 2023

PRIMARY

FDA UNII

X4BE7S8PN9

Created by admin on Sat Dec 16 19:10:07 GMT 2023 , Edited by admin on Sat Dec 16 19:10:07 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_7;1_12-1_36;2_1;2_6;2_8-2_9;2_11-2_13;2_15-2_22	47 / 58
2'-Fluoro-Ribose	1_8-1_11;2_2-2_5;2_7;2_10;2_14	11 / 58

Linkage	Site Range	Site Count
Phosporothioate	1_2;2_2-2_4;2_21-2_22	6 / 56
Phosphate	1_3-1_36;2_5-2_20	50 / 56

ACTIVE MOIETY


					X4BE7S8PN9

Lepodisiran