PHENOCOLL

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H14N2O2
Molecular Weight	194.2304
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC1=CC=C(NC(=O)CN)C=C1

InChI

InChIKey=LQJARUQXWJSDFL-UHFFFAOYSA-N

InChI=1S/C10H14N2O2/c1-2-14-9-5-3-8(4-6-9)12-10(13)7-11/h3-6H,2,7,11H2,1H3,(H,12,13)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18734338

Phenocoll is an antineuralgic, analgesic and antipyretic drug. It is a derivative of phenacetin and thus has the same mechanism of action (COX-2 inhibition). Hydrochloride and salicylate salts of phenocoll were used to control inflammation in such diseases as gout, influenza, malaria, rheumatism and pleuritis. The drug is no longer available for marketing.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin G/H synthase 2 51 Target ID: P35354 Gene ID: 5743.0 Gene Symbol: PTGS2 Target Organism: Homo sapiens (Human) Sources: http://www.google.com/patents/US8236355	Inhibitor 8504

Conditions

Condition	Modality	Highest Phase	Product
Gout 28 Sources: http://journals.lww.com/jonmd/Citation/1892/02000/Phenocoll_Hydrochlorate.4.aspx	Palliative	Approved 8583	Unknown Approved Use Unknown
Rheumatism 10 Sources: http://journals.lww.com/jonmd/Citation/1892/02000/Phenocoll_Hydrochlorate.4.aspx	Palliative	Approved 8583	Unknown Approved Use Unknown
Influenza virus infections 34 Sources: http://journals.lww.com/jonmd/Citation/1892/02000/Phenocoll_Hydrochlorate.4.aspx	Palliative	Approved 8583	Unknown Approved Use Unknown
Malaria 96 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18734338	Palliative	Approved 8583	Unknown Approved Use Unknown
Chorea 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18734338	Palliative	Approved 8583	Unknown Approved Use Unknown
Pleuritis 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18734338	Palliative	Approved 8583	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives.	1992-07-10	1321909
NEW AND NON-OFFICIAL REMEDIES.	1908-04	18734338

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose is 0.3 to 1.3 g, taken orally (dissolved in water before taking).

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

2-AMINO-N-(P-ETHOXYPHENYL)ACETAMIDE

Preferred Name

English

PHENOCOLL

Common Name

English

P-ACETOPHENETIDIDE, 2-AMINO-

Common Name

English

PHENAMIN

Common Name

English

PHENAMINE

Common Name

English

PHENOCOLL [MI]

Common Name

English

PHENOKOLL

Common Name

English

2-AMINO-P-ACETOPHENETIDIDE

Common Name

English

PHENAMIN (ANTIPYRETIC)

Common Name

English

Code System Code Type Description

DRUG CENTRAL

3437