Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C29H25N3O5 |
| Molecular Weight | 495.5259 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)[C@]1(C[C@H]2O[C@]1(C)N3C4=C(C=CC=C4)C5=C3C6=C(C7=C(C=CC=C7)N26)C8=C5CN(C)C8=O)OC
InChI
InChIKey=QTYMDECKVKSGSM-YMUMJAELSA-N
InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase Iα. | 2013-03 |
|
| Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression. | 2013-02-15 |
|
| Collagen IV contributes to nitric oxide-induced angiogenesis of lung endothelial cells. | 2011-05 |
|
| Dipyridamole suppresses high glucose-induced osteopontin secretion and mRNA expression in rat aortic smooth muscle cells. | 2010-06 |
|
| Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition. | 2010-04-23 |
|
| Protective effects of brain-derived neurotrophic factor against neurotoxicity of 3-nitropropionic acid in rat cortical neurons. | 2009-07 |
|
| Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells. | 2007-11 |
|
| Characterization of the relaxant response to N,N'-dipropyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine in porcine coronary arteries. | 2007-05 |
|
| Effect of manganese on luteinizing hormone-releasing hormone secretion in adult male rats. | 2007-05 |
|
| Manganese stimulates luteinizing hormone releasing hormone secretion in prepubertal female rats: hypothalamic site and mechanism of action. | 2007-02-01 |
|
| The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin. | 2006-02-15 |
|
| Effect of nitric oxide on mitogen-activated protein kinases in neonatal pulmonary vascular smooth muscle. | 2006-01-05 |
|
| Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis. | 2005-10 |
|
| Dipyridamole enhances tissue plasminogen activator release by brain capillary endothelial cells. | 2005 |
|
| Activation of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine isolated left anterior descending coronary artery by diosgenin. | 2004-10-11 |
|
| Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle. | 2004-03 |
|
| Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole. | 2003-06 |
|
| The specificities of protein kinase inhibitors: an update. | 2003-04-01 |
|
| Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy. | 2003 |
|
| Endothelin-1 and -3 diminish neuronal NE release through an NO mechanism in rat anterior hypothalamus. | 2002-09 |
|
| Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site. | 2000-07 |
|
| Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. | 1997-12-05 |
|
| Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells. | 1996-02-05 |
Sample Use Guides
KT5823 reduces radioactive iodide uptake (RAIU) activity and inhibits Na+/I− symporter (NIS) glycosylation in all human breast cancer cells examined. MCF-7, SK-BR-3, and MDA-MB-231 human breast cancer cells were transiently transfected with exogenous FLhNIS followed by treatment with 5 μM KT5823 for 16 h. It was shown, that KT5823 significantly reduced NIS-mediated RAIU activity in each human breast cancer cell line expressing exogenous hNIS. NIS-mediated iodide uptake activity was confirmed by comparing with parallel experiments conducted in the presence of perchlorate, an inhibitor of iodide uptake mediated by NIS.
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85102
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DTXSID40925642
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126643-37-6
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108152
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WY40BAB02W
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ACTIVE MOIETY
