Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C.Si |
| Molecular Weight | 40.0962 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[C-4].[Si+4]
InChI
InChIKey=CMGXHJPWLBFQMD-UHFFFAOYSA-N
InChI=1S/C.Si/q-4;+4
DescriptionCurator's Comment: description was created based on several sources, including
https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf
Curator's Comment: description was created based on several sources, including
https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf
Silicon dioxide (silica) is most commonly found in nature as quartz, as well as in various living organisms. Silicon dioxide one of the most complex and most abundant families of materials, existing both as several minerals and being produced synthetically. In food and pharmaceutical industry silica is a common additive, where it is used primarily as a flow in powdered foods, or to adsorb water in hygroscopic application. In pharmaceutical products, silica aids powder flow when tablets are formed.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Q9UEW3 Gene ID: 8685.0 Gene Symbol: MARCO Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Inactive ingredient | Oxycodone Hydrochloride Approved UseOxycodone is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics. Launch Date1998 |
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| Primary | Silicol gel Approved UseSilicol gel is an oral gel containing colloidal silicic acid for the treatment of gastrointestinal disorders. Taken 3 times a day it helps manage symptoms and provides relief for gastrointestinal discomfort. |
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| Primary | GELUSIL Approved UseUses
Relieves:
heartburn
sour stomach
acid indigestion
bloating, pressure and discomfort commonly referred to as gas Launch Date2008 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals. | 1994 Mar |
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| Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity. | 1996 Mar |
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| Blood gene expression profiling detects silica exposure and toxicity. | 2011 Aug |
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| Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling. | 2011 Dec |
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| Cytotoxicity and mitochondrial damage caused by silica nanoparticles. | 2011 Dec |
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| Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis. | 2011 Dec 1 |
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| Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages. | 2011 Jan 14 |
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| Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice. | 2011 Jun 10 |
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| TACE/TGF-α/EGFR regulates CXCL8 in bronchial epithelial cells exposed to particulate matter components. | 2011 Nov |
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| Altered microRNAs expression profiling in experimental silicosis rats. | 2012 |
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| Innate immune activation by inhaled lipopolysaccharide, independent of oxidative stress, exacerbates silica-induced pulmonary fibrosis in mice. | 2012 |
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| Aryl hydrocarbon receptor (AhR) regulates silica-induced inflammation but not fibrosis. | 2012 Apr |
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| Silica nanoparticles and silver-doped silica nanoparticles induce endoplasmatic reticulum stress response and alter cytochrome P4501A activity. | 2012 Apr |
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| Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats. | 2012 Aug |
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| Long-lasting oxidative pulmonary insult in rat after intratracheal instillation of silica nanoparticles doped with cadmium. | 2012 Dec 16 |
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| Immunostimulatory effects of gold nanorod and silica-coated gold nanorod on RAW 264.7 mouse macrophages. | 2012 Feb 25 |
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| Occupational and environmental cancer incidence and mortality in China. | 2012 Jun |
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| Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2. | 2012 Mar 1 |
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| Methylation of PARP-1 promoter involved in the regulation of nano-SiO2-induced decrease of PARP-1 mRNA expression. | 2012 Mar 25 |
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| Mechanisms of toxicity of amorphous silica nanoparticles on human lung submucosal cells in vitro: protective effects of fisetin. | 2012 Oct 15 |
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| Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro. | 2012 Oct 17 |
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| Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells. | 2012 Sep 28 |
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| Activation of Egr-1 in human lung epithelial cells exposed to silica through MAPKs signaling pathways. | 2013 |
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| New insight into artifactual phenomena during in vitro toxicity assessment of engineered nanoparticles: study of TNF-α adsorption on alumina oxide nanoparticle. | 2013 Apr |
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| Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats. | 2013 Apr |
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| The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells. | 2013 Aug |
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| Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications. | 2013 Aug 5 |
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| Comparative cytological responses of lung epithelial and pleural mesothelial cells following in vitro exposure to nanoscale SiO2. | 2013 Feb |
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| Cellular internalization and stress response of ingested amorphous silica nanoparticles in the midgut of Drosophila melanogaster. | 2013 Jan |
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| Toxicogenomic analysis of the particle dose- and size-response relationship of silica particles-induced toxicity in mice. | 2013 Jan 11 |
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| Evaluation of immunohistochemical markers to detect the genotoxic mode of action of fine and ultrafine dusts in rat lungs. | 2013 Jan 7 |
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| Interactions of silica nanoparticles with lung epithelial cells and the association to flotillins. | 2013 Jun |
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| Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines. | 2013 Jun 25 |
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| Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice. | 2013 Nov |
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| Suppression of thioredoxin system contributes to silica-induced oxidative stress and pulmonary fibrogenesis in rats. | 2013 Oct 9 |
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| PDGF-D expression is down-regulated by TGFβ in fibroblasts. | 2014 |
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| Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes. | 2014 Aug 1 |
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| Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling. | 2014 Aug 15 |
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| Uptake of silica nanoparticles: neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells. | 2014 Aug 17 |
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| Inflammation and gene expression in the rat lung after instillation of silica nanoparticles: effect of size, dispersion medium and particle surface charge. | 2014 Jan 3 |
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| Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle. | 2014 Jul 3 |
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| Role of size and surface area for pro-inflammatory responses to silica nanoparticles in epithelial lung cells: importance of exposure conditions. | 2014 Mar |
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| Si/SiO2 quantum dots cause cytotoxicity in lung cells through redox homeostasis imbalance. | 2014 Sep 5 |
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| miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells. | 2015 Aug 11 |
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| Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line. | 2015 Mar |
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| Aberrant cytokinesis and cell fusion result in multinucleation in HepG2 cells exposed to silica nanoparticles. | 2015 Mar 16 |
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| Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis. | 2015 Oct 15 |
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| Complex responses to Si quantum dots accumulation in carp liver tissue: Beyond oxidative stress. | 2015 Sep 5 |
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| Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents. | 2016 Feb |
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| Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice. | 2016 Feb |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.silicol.co.uk/
To treat gastrointestinal disorders, take one tablespoon (15ml) of silicol®gel (containing silicic acid which is a compound of silicon and oxygen) three times daily, preferably before mealtimes. After acute symptoms ease, treatment is recommended for another few days. For chronic conditions, treat for up to four weeks and then take a break to re-assess symptoms.
Route of Administration:
Oral
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681
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SILICON CARBIDE
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WXQ6E537EW
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409-21-2
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m9901
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206-991-8
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DTXSID5052751
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29390
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C022088
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SUBSTANCE RECORD
