Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C50H99NO9 |
| Molecular Weight | 858.3224 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@H](O)CCCCCCCCCCCCCC
InChI
InChIKey=VQFKFAKEUMHBLV-BYSUZVQFSA-N
InChI=1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42-,43+,44+,46-,47-,48-,49+,50-/m0/s1
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Characterization of neutral glycosphingolipids in rat lens. | 1995 Feb |
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| The crystal structure of human CD1d with and without alpha-galactosylceramide. | 2005 Aug |
|
| Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients. | 2005 May 2 |
|
| Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. | 2006 Mar 14 |
|
| Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions. | 2009 Aug 1 |
|
| Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy. | 2009 Sep |
|
| CD1d-dependent B-cell help by NK-like T cells leads to enhanced and sustained production of Bacillus anthracis lethal toxin-neutralizing antibodies. | 2010 Apr |
|
| Invariant NKT cells are required for antitumor responses induced by host-versus-graft responses. | 2010 Aug 15 |
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| A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. | 2010 Feb 15 |
|
| Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. | 2010 Jan 26 |
|
| Activation of Invariant NKT cells with glycolipid ligand α-galactosylceramide ameliorates glucose-6-phosphate isomerase peptide-induced arthritis. | 2012 |
|
| Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids. | 2012 |
|
| Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. | 2012 Mar 1 |
|
| Bacterial species-characteristic profiles of molecular species, and the antigenicity of phospholipids and glycolipids in symbiotic Lactobacillus, Staphylococcus and Streptococcus species. | 2012 May |
|
| Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide. | 2012 Sep 1 |
|
| Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. | 2013 |
|
| Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. | 2013 Jan 29 |
|
| Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells. | 2013 Sep 1 |
|
| Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection. | 2013 Sep 15 |
|
| Chronic alcohol consumption enhances iNKT cell maturation and activation. | 2015 Jan 15 |
Patents
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Code | English |
| Code System | Code | Type | Description | ||
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2826713
Created by
admin on Fri Dec 15 15:46:44 GMT 2023 , Edited by admin on Fri Dec 15 15:46:44 GMT 2023
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DTXSID40935847
Created by
admin on Fri Dec 15 15:46:44 GMT 2023 , Edited by admin on Fri Dec 15 15:46:44 GMT 2023
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C1720
Created by
admin on Fri Dec 15 15:46:44 GMT 2023 , Edited by admin on Fri Dec 15 15:46:44 GMT 2023
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WX671898JF
Created by
admin on Fri Dec 15 15:46:44 GMT 2023 , Edited by admin on Fri Dec 15 15:46:44 GMT 2023
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DB12232
Created by
admin on Fri Dec 15 15:46:44 GMT 2023 , Edited by admin on Fri Dec 15 15:46:44 GMT 2023
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158021-47-7
Created by
admin on Fri Dec 15 15:46:44 GMT 2023 , Edited by admin on Fri Dec 15 15:46:44 GMT 2023
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PRIMARY |
ACTIVE MOIETY
