GIRINIMBINE

CC1=C2OC(C)(C)C=CC2=C3NC4=C(C=CC=C4)C3=C1

InChIKey=GAEQWKVGMHUUKO-UHFFFAOYSA-N

InChI=1S/C18H17NO/c1-11-10-14-12-6-4-5-7-15(12)19-16(14)13-8-9-18(2,3)20-17(11)13/h4-10,19H,1-3H3

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin G/H synthase (cyclooxygenase) 4 Target ID: CHEMBL2111358 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8053931	Inhibitor 8297
angiogenesis 17 Target ID: GO:0001525 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25767375	Inhibitor 8297
Oxidative Stress 160 Target ID: WP408 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22522395	Inhibitor 8297
Apoptosis 155 Target ID: map04210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21862957 \| https://www.ncbi.nlm.nih.gov/pubmed/30084434 \| https://www.ncbi.nlm.nih.gov/pubmed/12450250 \| https://www.ncbi.nlm.nih.gov/pubmed/23573145	Activator 1430

PubMed

Title	Date	PubMed
Anti-trichomonal, biochemical and toxicological activities of methanolic extract and some carbazole alkaloids isolated from the leaves of Murraya koenigii growing in Nigeria.	2006 Mar	16492527
Murrayakoeninol--a new carbazole alkaloid from Murraya koenigii (Linn) Spreng.	2009 Mar	19413112
Efficient iron-mediated approach to pyrano[3,2-a]carbazole alkaloids--first total syntheses of O-methylmurrayamine A and 7-methoxymurrayacine, first asymmetric synthesis and assignment of the absolute configuration of (-)-trans-dihydroxygirinimbine.	2011 Apr 7	21279228
Pleiotropic Effect of Mahanine and Girinimbine Analogs: Anticancer Mechanism and its Therapeutic Versatility.	2018	30173653
[Chemical constituents from stems and leaves of Clausena emarginata].	2019 May	31355567

Name

Type

Language

GIRINIMBINE

Common Name

English

Pyrano[3,2-a]carbazole, 3,11-dihydro-3,3,5-trimethyl-

Systematic Name

English

NSC-94932

Code

English

3,3,5-Trimethyl-11H-pyrano[3,2-a]carbazole

Systematic Name

English

Girinimbin

Common Name

English

3,11-Dihydro-3,3,5-trimethylpyrano[3,2-a]carbazole

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

Girinimbine