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Details

Stereochemistry ACHIRAL
Molecular Formula C18H18FN3.2ClH
Molecular Weight 368.276
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CARVOTROLINE DIHYDROCHLORIDE

SMILES

Cl.Cl.FC1=CC2=C(NC3=C2CN(CCC4=CC=NC=C4)CC3)C=C1

InChI

InChIKey=JZKBIAMJBKEKGP-UHFFFAOYSA-N
InChI=1S/C18H18FN3.2ClH/c19-14-1-2-17-15(11-14)16-12-22(10-6-18(16)21-17)9-5-13-3-7-20-8-4-13;;/h1-4,7-8,11,21H,5-6,9-10,12H2;2*1H

HIDE SMILES / InChI
Carvotroline [WY 47791] is a novel γ-carboline derivative with a preclinical profile suggestive of antipsychotic activity. Carvotroline has an affinity for the dopamine D2 receptor and cortical 5-HT2 receptor that is ten times greater than serotonin. Carvotroline administration to rats leads to a decrease of plasma corticosterone levels and demonstrated a moderating effect on the rotational-stress induced rise in plasma corticosterone levels.

Approval Year

PubMed

PubMed

TitleDatePubMed
Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat.
1997 Aug
Patents

Patents

Sample Use Guides

rat 7.0 mg/kg
Route of Administration: Intraperitoneal
Name Type Language
CARVOTROLINE DIHYDROCHLORIDE
Common Name English
1H-PYRIDO(4,3-B)INDOLE, 8-FLUORO-2,3,4,5-TETRAHYDRO-2-(2-(4-PYRIDINYL)ETHYL)-, HYDROCHLORIDE (1:2)
Systematic Name English
Code System Code Type Description
PUBCHEM
13772459
Created by admin on Fri Dec 15 15:58:02 GMT 2023 , Edited by admin on Fri Dec 15 15:58:02 GMT 2023
PRIMARY
FDA UNII
WGF75067BR
Created by admin on Fri Dec 15 15:58:02 GMT 2023 , Edited by admin on Fri Dec 15 15:58:02 GMT 2023
PRIMARY
EPA CompTox
DTXSID70147991
Created by admin on Fri Dec 15 15:58:02 GMT 2023 , Edited by admin on Fri Dec 15 15:58:02 GMT 2023
PRIMARY
CAS
107266-20-6
Created by admin on Fri Dec 15 15:58:02 GMT 2023 , Edited by admin on Fri Dec 15 15:58:02 GMT 2023
PRIMARY