N-NITROSO-N-METHYLUREA

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H5N3O2
Molecular Weight	103.08
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(N=O)C(N)=O

InChI

InChIKey=ZRKWMRDKSOPRRS-UHFFFAOYSA-N

InChI=1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea.	2002-05-28	11888666
Synergistic tumor promoter effects of estrone and progesterone in methylnitrosourea-induced rat mammary cancer.	2002-05-28	11888665
Induction of stem cell cycling in mice increases their sensitivity to a chemical leukaemogen: implications for inherited genomic instability and the bystander effect.	2002-04-25	11934433
Selective depletion of human DNA-methyltransferase DNMT1 proteins by sulfonate-derived methylating agents.	2002-03-15	11912126
PARP-1 modifies the effectiveness of p53-mediated DNA damage response.	2002-02-07	11850828
Chemoprevention of N-methylnitrosourea-induced colon carcinogenesis by ursodeoxycholic acid-5-aminosalicylic acid conjugate in F344 rats.	2002-02	11856477
Helicobacter pylori does not promote N-methyl-N-nitrosourea-induced gastric carcinogenesis in SPF C57BL/6 mice.	2002-02	11856473
Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4.	2002-02	11813303
Semi-automated method of quantifying vasculature of 1-methyl-1-nitrosourea-induced rat mammary carcinomas using immunohistochemical detection.	2002-02	11799140
The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas.	2002-01-10	11803473
Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancer.	2002-01	11807958
Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen-independent, but responsive to d-limonene treatment.	2002-01	11802805
LAS, a novel selective estrogen receptor modulator with chemopreventive and therapeutic activity in the N-nitroso-N-methylurea-induced rat mammary tumor model.	2001-12-15	11751385
Identification of rat mammary tumor-1 gene (RMT-1), which is highly expressed in rat mammary tumors.	2001-12-10	11675151
Effect of lactobacilli, bifidobacteria and inulin on the formation of aberrant crypt foci in rats.	2001-12	11876494
Effect of the aromatase inhibitor vorozole on estrogen and progesterone receptor content of rat mammary carcinomas induced by 1-methyl-1-nitrosourea.	2001-12	11804181
Detection of tumorigenesis in rat bladders with optical coherence tomography.	2001-12	11797946
Mechanisms of hormonal prevention of breast cancer.	2001-12	11795441
[Mutagenic effect of nitrosomethylurea, modified by heat shock at early stages of sunflower seedling development].	2001-12	11785291
Growth and characterization of N-methyl-N-nitrosourea-induced mammary tumors in intact and ovariectomized rats.	2001-12	11751437
Chemoprevention of mammary, cervix and nervous system carcinogenesis in animals using cultured Panax ginseng drugs and preliminary clinical trials in patients with precancerous lesions of the esophagus and endometrium.	2001-12	11748376
Altered gene expression profile in chemically induced rat mammary adenocarcinomas and its modulation by an aromatase inhibitor.	2001-11-22	11753649
Overexpression of Ogt reduces MNU and ENU induced transition, but not transversion, mutations in E. coli.	2001-11-01	11595408
Effect of dietary zinc intake on N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats.	2001-11	11762533
Organotropic chemopreventive effects of n-3 unsaturated fatty acids in a rat multi-organ carcinogenesis model.	2001-11	11714441
Transgenerational effects of preconception paternal contamination with (55)Fe.	2001-11	11604061
A technetium-99m-labelled cyclam acid porphyrin (CAP) for tumour imaging.	2001-11	11573797
Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.	2001-10-15	11606380
Role of RAD51 in sister-chromatid exchanges in mammalian cells.	2001-10-04	11641788
Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic.	2001-10	11817103
Early exposure of the rat mammary gland to estrogen and progesterone blocks co-localization of estrogen receptor expression and proliferation.	2001-10	11572792
MMTV promoter hypomethylation is linked to spontaneous and MNU associated c-neu expression and mammary carcinogenesis in MMTV c-neu transgenic mice.	2001-09-20	11593408
Evaluation of the chemopreventive potential of retinoids using a novel in vitro human prostate carcinogenesis model.	2001-09-20	11551491
Para-aminobenzoic acid inhibits a set of SOS functions in Escherichia coli K12.	2001-09-20	11551484
Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells.	2001-09-01	11506814
Mammary gland carcinoma-related increase of type I iodothyronine 5'-deiodinase activity in Sprague-Dawley rats.	2001-09	11765219
MNU induction of neoplasia in a platyfish model.	2001-09	11555667
Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice.	2001-09	11532874
Overexpression of human O6-alkylguanine DNA alkyltransferase (AGT) prevents MNU induced lymphomas in heterozygous p53 deficient mice.	2001-08-30	11536039
Proteome analysis of rat hepatomas: carcinogen-dependent tumor-associated protein variants.	2001-08	11565795
AP-1 mediated retinal photoreceptor apoptosis is independent of N-terminal phosphorylation of c-Jun.	2001-08	11526439
The comet assay detects adaptation to MNU-induced DNA damage in barley.	2001-06-27	11516719
DNA damage and repair in Arabidopsis thaliana as measured by the comet assay after treatment with different classes of genotoxins.	2001-06-27	11516718
Diesel exhaust-induced airway hyperresponsiveness in c-Ha-ras transgenic mice.	2001-06-21	11516524
[Aranoza -- a new Russian antineoplastic drug].	2001	11826486
[Nitrosomethylurea -- 30 years of study and use in the treatment of cancer patients].	2001	11826484
Alkylating agent (MNU)-induced mutation in space environment.	2001	11799989
The effects of microgravity on induced mutation in Escherichia coli and Saccharomyces cerevisiae.	2001	11799988
Preventive effects of raloxifene and melatonin in N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats.	2001	11712685
CB6F1-rasH2 mouse: overview of available data.	2001	11695565

Patents

Name

Type

Language

NSC-23909

Preferred Name

English

N-NITROSO-N-METHYLUREA

Systematic Name

English

MNU

Common Name

English

N-NITROSO-N-METHYLUREA [HSDB]

Common Name

English

NMU

Common Name

English

METHYLNITROSOUREA

Systematic Name

English

1-NITROSO-1-METHYLUREA

Systematic Name

English

UREA, N-METHYL-N-NITROSO-

Systematic Name

English

NMH

Common Name

English

N-NITROSO-N-METHYLCARBAMIDE

Common Name

English

NITROSOMETHYLUREA

Systematic Name

English

N-METHYL-N-NITROSOUREA [IARC]

Common Name

English

1-METHYL-1-NITROSOUREA

Systematic Name

English

UREA, 1-METHYL-1-NITROSO-

Systematic Name

English

N-METHYL-N-NITROSOUREA

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C699