Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C22H29NO2.C10H8O3S |
Molecular Weight | 547.705 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(=O)(=O)C1=CC2=C(C=CC=C2)C=C1.CCC(=O)O[C@](CC3=CC=CC=C3)([C@@H](C)CN(C)C)C4=CC=CC=C4
InChI
InChIKey=VZPXFHVJUUSVLH-VNJAQMQMSA-N
InChI=1S/C22H29NO2.C10H8O3S/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h6-15,18H,5,16-17H2,1-4H3;1-7H,(H,11,12,13)/t18-,22+;/m0./s1
DescriptionSources: https://www.drugbank.ca/drugs/DB06793
Sources: https://www.drugbank.ca/drugs/DB06793
LEVOPROPOXYPHENE is an antitussive drug, one of enantiomer of propoxyphene. Pdropoxyphene is an analgesic in the opioid category, patented in 1955 and manufactured by Eli Lilly and Company. Pdropoxyphene is intended to treat mild pain and also has antitussive (cough suppressant) and local anaesthetic effects.
Originator
Approval Year
Doses
Dose | Population | Adverse events |
---|---|---|
100 mg 6 times / day multiple, oral Highest studied dose Dose: 100 mg, 6 times / day Route: oral Route: multiple Dose: 100 mg, 6 times / day Sources: |
unhealthy, adult n = 50 Health Status: unhealthy Condition: nonproductive cough Age Group: adult Sex: M+F Population Size: 50 Sources: |
Disc. AE: Nausea... AEs leading to discontinuation/dose reduction: Nausea Sources: |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Nausea | Disc. AE | 100 mg 6 times / day multiple, oral Highest studied dose Dose: 100 mg, 6 times / day Route: oral Route: multiple Dose: 100 mg, 6 times / day Sources: |
unhealthy, adult n = 50 Health Status: unhealthy Condition: nonproductive cough Age Group: adult Sex: M+F Population Size: 50 Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
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Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
no [Activation >10 uM] | ||||
no [Activation >10 uM] | ||||
no [Activation >10 uM] | ||||
yes [Activation 5.01187 uM] | ||||
yes [Activation 7.94328 uM] |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4815955
The disposition of propoxyphene and its major biotransformation product norpropoxyphene was studied in normal subjects following a single 130 mg oral dose.
Route of Administration:
Oral
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C66917
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W7DQT6KY5S
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227-209-1
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6604497
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DBSALT001392
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m6793
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CHEMBL1738990
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C90775
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DTXSID8045563
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ACTIVE MOIETY
SUBSTANCE RECORD