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Details

Stereochemistry RACEMIC
Molecular Formula C15H22N2O4
Molecular Weight 294.3462
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TROXIPIDE

SMILES

COC1=CC(=CC(OC)=C1OC)C(=O)NC2CCCNC2

InChI

InChIKey=YSIITVVESCNIPR-UHFFFAOYSA-N
InChI=1S/C15H22N2O4/c1-19-12-7-10(8-13(20-2)14(12)21-3)15(18)17-11-5-4-6-16-9-11/h7-8,11,16H,4-6,9H2,1-3H3,(H,17,18)

HIDE SMILES / InChI

Description

Tripoxide is a gastric cytoprotective agent used for the treatment of gastritis and gastric uclers in Japan, India, China and South Korea. Troxipide has a mode of action different from that for other anti-gastric agents: it does not inhibit acid secretion and does not have acid neutralizing activity. It exerts its activity by increasing mucus production, cytoprotective prostaglandin secretion, regeneration of collagen fibers, reducing inflammatory mediator induced neutrophil migration and reactive oxygen species generation in gastric mucosa, enhancing gastric mucosal metabolism and microcirculation.

CNS Activity

PMID

PMID

TitleDatePMID
Troxipide in the management of gastritis: a randomized comparative trial in general practice.
2010
Patent

Patent

Sample Use Guides

In Vivo Use Guide
The usual adult dosage for oral use is 100 mg of troxipide (one tablet or 0.5 g of fine granules) three times daily after meals.
Route of Administration: Oral
In Vitro Use Guide
Incubation of neutrophils with 10(-6) to 10(4) M troxipide caused inhibition of recombinant interleukin-8-induced migration.
Name Type Language
TROXIPIDE
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
TROXIPIDE [MART.]
Common Name English
TROXIPIDE [MI]
Common Name English
TROXIPIDE [JAN]
Common Name English
TROXIPIDE [INN]
Common Name English
(+/-)-3,4,5-TRIMETHOXY-N-3-PIPERIDYLBENZAMIDE
Systematic Name English
TROXIPIDE [WHO-DD]
Common Name English
APLACE
Brand Name English
Classification Tree Code System Code
WHO-VATC QA02BX11
Created by admin on Tue Mar 06 11:19:11 UTC 2018 , Edited by admin on Tue Mar 06 11:19:11 UTC 2018
WHO-ATC A02BX11
Created by admin on Tue Mar 06 11:19:11 UTC 2018 , Edited by admin on Tue Mar 06 11:19:11 UTC 2018
Code System Code Type Description
CAS
30751-05-4
Created by admin on Tue Mar 06 11:19:11 UTC 2018 , Edited by admin on Tue Mar 06 11:19:11 UTC 2018
PRIMARY
ChEMBL
CHEMBL1566956
Created by admin on Tue Mar 06 11:19:11 UTC 2018 , Edited by admin on Tue Mar 06 11:19:11 UTC 2018
PRIMARY
PUBCHEM
5597
Created by admin on Tue Mar 06 11:19:11 UTC 2018 , Edited by admin on Tue Mar 06 11:19:11 UTC 2018
PRIMARY SWITZERF
MERCK INDEX
M11240
Created by admin on Tue Mar 06 11:19:11 UTC 2018 , Edited by admin on Tue Mar 06 11:19:11 UTC 2018
PRIMARY Merck Index
WIKIPEDIA
TROXIPIDE
Created by admin on Tue Mar 06 11:19:11 UTC 2018 , Edited by admin on Tue Mar 06 11:19:11 UTC 2018
PRIMARY
INN
5461
Created by admin on Tue Mar 06 11:19:11 UTC 2018 , Edited by admin on Tue Mar 06 11:19:11 UTC 2018
PRIMARY
EPA CompTox
30751-05-4
Created by admin on Tue Mar 06 11:19:11 UTC 2018 , Edited by admin on Tue Mar 06 11:19:11 UTC 2018
PRIMARY
EVMPD
SUB11353MIG
Created by admin on Tue Mar 06 11:19:11 UTC 2018 , Edited by admin on Tue Mar 06 11:19:11 UTC 2018
PRIMARY