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Details

Stereochemistry RACEMIC
Molecular Formula C13H21NO2.ClH
Molecular Weight 259.772
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TOLIPROLOL HYDROCHLORIDE

SMILES

Cl.CC(C)NCC(O)COC1=CC=CC(C)=C1

InChI

InChIKey=UFLVPYQUIGXQNW-UHFFFAOYSA-N
InChI=1S/C13H21NO2.ClH/c1-10(2)14-8-12(15)9-16-13-6-4-5-11(3)7-13;/h4-7,10,12,14-15H,8-9H2,1-3H3;1H

HIDE SMILES / InChI
Toliprolol is beta-adrenergic blocker. It was developed as antianginal and antihypertensive agent. Toliprolol is moderately lipophilic. It appears to have the appropriate characteristics for cerebral beta-adrenoreceptor imaging. However, tissue uptake of toliprolol was dominated by the nonspecific binding, both in the brain and in peripheral target organs, such as heart and lung. Toliprolol seems unsuitable for visualization of cerebral beta-adrenoceptors. After application of ethanol to mice, the content of glycogen of the liver and the brain decreased. By pretreatment with the beta-sympatholytic agent toliprolol, the ethanol-induced break-down of glycogen was partially blocked in the liver and completely abolished in the brain. In contrast, mainly synergistic effects of ethanol and toliprolol on the glycolysis of the liver and the brain were found. Toliprolol reduced the greater variance during the emotionally stressful situation in doses insufficient to diminish the mean increase in forearm blood flow.

Approval Year

PubMed

PubMed

TitleDatePubMed
Tremorine-oxotremorine-induced tremor, hypothermia and analgesia, and physostigmine toxicity, in mice after pretreatment with beta-adrenoceptor antagonists.
1976 Apr
Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man.
2001 Apr 27
Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET.
2002 Feb
Facile radiosynthesis of fluorine-18 labeled beta-blockers. Synthesis, radiolabeling, and ex vivo biodistribution of [18F]-(2S and 2R)-1-(1-fluoropropan-2-ylamino)-3-(m-tolyloxy)propan-2-ol.
2008 Aug 28

Sample Use Guides

Single dose - 50 ug/g
Route of Administration: Other
Name Type Language
TOLIPROLOL HYDROCHLORIDE
MI  
Common Name English
TOLIPROLOL HCL
Common Name English
1-((1-METHYLETHYL)AMINO)-3-(3-METHYLPHENOXY)-2-PROPANOL HYDROCHLORIDE
Systematic Name English
1-(ISOPROPYLAMINO)-3-(M-TOLYLOXY)-2-PROPANOL HYDROCHLORIDE
Systematic Name English
TOLIPROLOL HYDROCHLORIDE [MI]
Common Name English
KO 592
Code English
ICI-45763
Code English
1-(3-METHYLPHENOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL HYDROCHLORIDE
Systematic Name English
1-(3-METHYLPHENOXY)-2-HYDROXY-3-ISOPROPYLAMINOPROPANE HYDROCHLORIDE
Systematic Name English
ICI 45763
Code English
KO-592
Code English
Classification Tree Code System Code
NCI_THESAURUS C29576
Created by admin on Fri Dec 15 17:32:12 GMT 2023 , Edited by admin on Fri Dec 15 17:32:12 GMT 2023
Code System Code Type Description
FDA UNII
W5968X3S7N
Created by admin on Fri Dec 15 17:32:12 GMT 2023 , Edited by admin on Fri Dec 15 17:32:12 GMT 2023
PRIMARY
CAS
306-11-6
Created by admin on Fri Dec 15 17:32:12 GMT 2023 , Edited by admin on Fri Dec 15 17:32:12 GMT 2023
PRIMARY
MERCK INDEX
m1264
Created by admin on Fri Dec 15 17:32:12 GMT 2023 , Edited by admin on Fri Dec 15 17:32:12 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
206-177-2
Created by admin on Fri Dec 15 17:32:12 GMT 2023 , Edited by admin on Fri Dec 15 17:32:12 GMT 2023
PRIMARY
NCI_THESAURUS
C90804
Created by admin on Fri Dec 15 17:32:12 GMT 2023 , Edited by admin on Fri Dec 15 17:32:12 GMT 2023
PRIMARY
PUBCHEM
120651
Created by admin on Fri Dec 15 17:32:12 GMT 2023 , Edited by admin on Fri Dec 15 17:32:12 GMT 2023
PRIMARY
MESH
C073327
Created by admin on Fri Dec 15 17:32:12 GMT 2023 , Edited by admin on Fri Dec 15 17:32:12 GMT 2023
PRIMARY
EPA CompTox
DTXSID20952875
Created by admin on Fri Dec 15 17:32:12 GMT 2023 , Edited by admin on Fri Dec 15 17:32:12 GMT 2023
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