GSK-2816126

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C31H38N6O2
Molecular Weight	526.6724
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC[C@H](C)N1C=C(C)C2=C1C=C(C=C2C(=O)NCC3=C(C)C=C(C)NC3=O)C4=CC=C(N=C4)N5CCNCC5

InChI

InChIKey=FKSFKBQGSFSOSM-QFIPXVFZSA-N

InChI=1S/C31H38N6O2/c1-6-22(5)37-18-20(3)29-25(30(38)34-17-26-19(2)13-21(4)35-31(26)39)14-24(15-27(29)37)23-7-8-28(33-16-23)36-11-9-32-10-12-36/h7-8,13-16,18,22,32H,6,9-12,17H2,1-5H3,(H,34,38)(H,35,39)/t22-/m0/s1

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histone-lysine N-methyltransferase EZH2 10 Target ID: Q15910\|\|\|Q96FI6 Gene ID: 2146.0 Gene Symbol: EZH2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28978137 \| https://www.ncbi.nlm.nih.gov/pubmed/29473431	Inhibitor 8297

Name

Type

Language

GSK-2816126

Common Name

English

GSK-2816126A

Code

English

1H-INDOLE-4-CARBOXAMIDE, N-((1,2-DIHYDRO-4,6-DIMETHYL-2-OXO-3-PYRIDINYL)METHYL)-3-METHYL-1-((1S)-1-METHYLPROPYL)-6-(6-(1-PIPERAZINYL)-3-PYRIDINYL)-

Systematic Name

English

GSK-126

Code

English

GSK 2816126 [WHO-DD]

Common Name

English

(S)-1-(SEC-BUTYL)-N-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-3-METHYL-6-(6-(PIPERAZIN-1-YL)PYRIDIN-3-YL)-1H-INDOLE-4-CARBOXAMIDE

Systematic Name

English

N-((1,2-DIHYDRO-4,6-DIMETHYL-2-OXO-3-PYRIDINYL)METHYL)-3-METHYL-1-((1S)-1-METHYLPROPYL)-6-(6-(1-PIPERAZINYL)-3-PYRIDINYL)-1H-INDOLE-4-CARBOXAMIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

W4OGW9QZ97